Terhi T. Piltonen, Paolo Giacobini, Åsa Edvinsson, Steinar Hustad, Susanne Lager, Laure Morin-Papunen, Juha S. Tapanainen, Inger Sundström-Poromaa, Riikka K. Arffman, Circulating antimüllerian hormone and steroid hormone levels remain high in pregnant women with polycystic ovary syndrome at term, Fertility and Sterility, Volume 111, Issue 3, 2019, Pages 588-596.e1, ISSN 0015-0282, https://doi.org/10.1016/j.fertnstert.2018.11.028
Circulating antimüllerian hormone and steroid hormone levels remain high in pregnant women with polycystic ovary syndrome at term
|Author:||Piltonen, Terhi T.1; Giacobini, Paolo2; Edvinsson, Åsa3;|
1Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
2Jean-Pierre Aubert Research Center, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Institut National de la Santé et de la Recherche Médicale, Lille, France
3Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
4Department of Clinical Science, University of Bergen, Bergen, Norway
5Core Facility for Metabolomics, University of Bergen, Bergen, Norway
6Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
|Online Access:||PDF Full Text (PDF, 0.4 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019070922943
|Publish Date:|| 2019-07-09
Objective: To investigate plasma antimüllerian hormone (AMH) concentration and its relation to steroid hormone levels in pregnant women with polycystic ovary syndrome (PCOS) and controls at term.
Design: Case–control study.
Setting: University-affiliated hospital.
Patient(s): A total of 74 pregnant women at term: 25 women with PCOS (aged 31.6 ± 3.9 years [mean ± standard deviation], body mass index 24.0 ± 3.9 kg/m², mean gestational length 279 ± 9 days) and 49 controls (aged 31.7 ± 3.3 years, body mass index 24.0 ± 3.3 kg/m², mean gestational length 281 ± 9 days).
Main Outcome Measure(s): Plasma AMH and steroid hormone levels.
Result(s): Antimüllerian hormone, T, and androstenedione levels were higher in women with PCOS at term compared with controls, whereas estrogen and P levels were similar. The differences were pronounced in women carrying a female fetus. Testosterone and AMH levels correlated positively in both groups, but E₂ levels only in women with PCOS.
Conclusion(s): Pregnant women with PCOS present with elevated AMH and androgen levels even at term, suggesting a hormonal imbalance during PCOS pregnancy. Differences were detected especially in pregnancies with a female fetus, raising the question of whether female pregnancies are more susceptible to AMH and steroid hormone actions.
Fertility and sterility
|Pages:||588 - 596.e1|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
© 2018 The Authors. Published by Elsevier Inc. on behalf of the American Society for Repro-ductive Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).