University of Oulu

Salla Karjula, Laure Morin-Papunen, Juha Auvinen, Aimo Ruokonen, Katri Puukka, Stephen Franks, Marjo-Riitta Järvelin, Juha S. Tapanainen, Jari Jokelainen, Jouko Miettunen, Terhi T. Piltonen, Psychological Distress Is More Prevalent in Fertile Age and Premenopausal Women With PCOS Symptoms: 15-Year Follow-Up, The Journal of Clinical Endocrinology & Metabolism, Volume 102, Issue 6, 1 June 2017, Pages 1861–1869, https://doi.org/10.1210/jc.2016-3863

Psychological distress is more prevalent in fertile age and premenopausal women with PCOS symptoms : 15-year follow-up

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Author: Karjula, Salla1,2,3; Morin-Papunen, Laure1,2,3; Auvinen, Juha2,4;
Organizations: 1Department of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, FI-90014 Oulu, Finland
2Medical Research Center, University Hospital of Oulu, University of Oulu, FI-90014 Oulu, Finland
3PEDEGO Research Unit, University Hospital of Oulu, University of Oulu, FI-90014 Oulu, Finland
4Center for Life Course Health Research, University Hospital of Oulu, University of Oulu, FI-90014 Oulu, Finland
5NordLab Oulu, Department of Clinical Chemistry, University Hospital of Oulu, University of Oulu, FI-90014 Oulu, Finland
6Institute of Reproductive and Developmental Biology, Imperial College London, London W12 ONN, United Kingdom
7Center for Life Course Epidemiology, Faculty of Medicine, University Hospital of Oulu, University of Oulu, FI-90014 Oulu, Finland
8Department of Epidemiology and Biostatistics, Medical Research Council-Public Health England Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, United Kingdom
9Department of Obstetrics and Gynecology, University of Helsinki, Helsinki University Hospital, FI-00014 Helsinki, Finland
10Faculty of Medicine, University of Oulu, FI-90014 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019073023232
Language: English
Published: Endocrine society, 2017
Publish Date: 2019-07-30
Description:

Abstract

Context: Polycystic ovary syndrome (PCOS) is associated with increased psychological distress, obesity and hyperandrogenism being suggested as key promoters.

Objectives: To investigate the prevalence of anxiety/depression and their coexistence in women with PCOS/PCOS-related symptoms at ages 31 and 46. The roles of obesity, hyperandrogenism, and awareness of PCOS on psychological distress were also assessed.

Design: Population-based follow-up.

Setting: Northern Finland Birth Cohort 1966 with 15-year follow-up.

Participants: At age 31, a questionnaire-based screening for oligoamenorrhea (OA) and hirsutism (H): 2188 asymptomatic (controls), 331 OA, 323 H, and 125 OA plus H (PCOS). Follow-up at age 46: 1576 controls, 239 OA, 231 H, and 85 PCOS.

Interventions: Questionnaire-based screening for anxiety and depression symptoms (Hopkins Symptom Checklist-25) and previously diagnosed/treated depression at ages 31 and 46. Body mass index (BMI), serum testosterone/free androgen index, and awareness of polycystic ovaries/PCOS on psychological distress were also assessed.

Main Outcomes: Population-based prevalence of anxiety and/or depression in women with PCOS/PCOS-related symptoms at ages 31 and 46.

Results: Anxiety and/or depression symptoms, their coexistence, and rate of depression were increased at ages 31 and 46 in women with PCOS or isolated H compared with controls. High BMI or hyperandrogenism did not associate with increased anxiety or depression symptoms. The awareness of PCOS was associated with increased anxiety.

Conclusions: Women with PCOS or isolated H present more often with anxiety and/or depression symptoms and their coexistence compared with controls. High BMI or hyperandrogenism did not provoke psychological distress in PCOS. The awareness of PCOS increased anxiety but did not associate with severe anxiety or depression.

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Series: Journal of clinical endocrinology & metabolism
ISSN: 0021-972X
ISSN-E: 1945-7197
ISSN-L: 0021-972X
Volume: 102
Issue: 6
Pages: 1861 - 1869
DOI: 10.1210/jc.2016-3863
OADOI: https://oadoi.org/10.1210/jc.2016-3863
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
Funding: This work was supported by the Academy of Finland (Project Grants 104781, 120315, 129269, 1114194, 268336, and SALVE); Sigrid Juselius Foundation; Finnish Medical Foundation; North Ostrabothnia Regional Fund; Northern Finland Health Care Support Foundation; University Hospital of Oulu, Biocenter Oulu, and Medical Research Center Oulu, University of Oulu (75617); European Commission (EURO- BLCS, Framework 5 Award QLG1-CT-2000-01643); National Institute for Health Research (United Kingdom); and Medical Research Council Grant G0802782 (United Kingdom).
Academy of Finland Grant Number: 104781
120315
129269
1114194
268336
Detailed Information: 104781 (Academy of Finland Funding decision)
120315 (Academy of Finland Funding decision)
129269 (Academy of Finland Funding decision)
1114194 (Academy of Finland Funding decision)
268336 (Academy of Finland Funding decision)
Copyright information: This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).
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