University of Oulu

Yang, Y., Shi, Y., Wiklund, P., Tan, X., Wu, N., Zhang, X., … Cheng, S. (2017). The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women. Nutrients, 9(8), 792. https://doi.org/10.3390/nu9080792

The association between cardiorespiratory fitness and gut microbiota composition in premenopausal women

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Author: Yang, Yifan1,2; Shi, Yi2,3; Wiklund, Petri4,5,6,7;
Organizations: 1 School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
2Exercise, Health and Technology center, Shanghai Jiao Tong University, Shanghai 200240, China
3Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China
4 Exercise, Health and Technology center, Shanghai Jiao Tong University, Shanghai 200240, China
5 Faculty of Sport and Health Sciences, University of Jyvaskyla, 40014 Jyvaskyla, Finland
6Center for Life Course Epidemiology, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
7Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, SW7 2AZ London, UK
8School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
9State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
10Department of Medical Microbiology and Immunology, University of Turku, 20014 Turku, Finland
11Faculty of Sport and Health Sciences, University of Jyvaskyla, 40014 Jyvaskyla, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019080123347
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2019
Publish Date: 2019-08-01
Description:

Abstract

The aim of this study was to investigate the association between cardiorespiratory fitness and gut microbiota composition in premenopausal women. The participants consisted of 71 premenopausal Finnish women (aged 19–49 years). Gut microbiota were analyzed using flow cytometry, 16S rRNA gene hybridization and DNA-staining. Maximum oxygen uptake (VO₂ₘₐₓ) was assessed by respiratory gas analyzer and body composition by Bioimpdance. We found that participants with low VO₂ₘₐₓ had lower Bacteroides, but higher Eubacterium rectale-Clostridium coccoides than the high VO₂ₘₐₓ group (p < 0.05 for all). VO₂ₘₐₓ was inversely associated with EreC (r = −0.309, p = 0.01) but not with other bacteria. VO₂ₘₐₓ also negatively correlated with fat% (r = −0.755, p < 0.001), triglycerides (r = −0.274, p = 0.021) and leptin (r = −0.574, p < 0.001). By contrast, EreC was positively associated with fat% (r = 0.382, p = 0.002), dietary fat intake (r = 0.258, p = 0.034), triglycerides (r = 0.390, p = 0.002) and leptin (r = 0.424, p = 0.001), but negatively with carbohydrate intake (r = −0.252, p = 0.034) and HDL (r = −0.26, p = 0.028). After adjusting for age and dietary intake, all the significant associations remained. However, after adjusting for fat%, the associations between VO₂ₘₐₓ and EreC disappeared. Our results suggest that cardiorespiratory fitness is associated with gut microbiota composition, independent of age and carbohydrate or fat intake. The association between VO₂ₘₐₓ and EreC, however, appears to be mediated by body fatness.

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Series: Nutrients
ISSN: 2072-6643
ISSN-E: 2072-6643
ISSN-L: 2072-6643
Volume: 9
Issue: 8
Article number: 792
DOI: 10.3390/nu9080792
OADOI: https://oadoi.org/10.3390/nu9080792
Type of Publication: A1 Journal article – refereed
Field of Science: 3141 Health care science
315 Sport and fitness sciences
Subjects:
Funding: Funding for this study was provided by the Academy of Finland (Grant 24302031), China State Sport General Administration (2015B039), the National Natural Science Foundation of China (NSFC 31571219), and the Shanghai Jiao Tong University Zhiyuan Foundation (CP2014013).
Academy of Finland Grant Number: 24302031
Detailed Information: 24302031 (Academy of Finland Funding decision)
Copyright information: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/