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Coincidence of pollen season with the first fetal trimester together with early pet exposure is associated with sensitisation to cat and dog allergens in early childhood : a Finnish population-based study |
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| Author: | Pyrhönen, K.1; Kulmala, P.2,3; Näyhä, S.4 |
| Organizations: |
1Center for Life Course Health Research,University of Oulu, Oulu, Finland 2PEDEGO Research Unit and MRC Oulu,University of Oulu and Oulu University Hospital, Oulu, Finland 3Biomedicine Research Unit, Medical Microbiology and Immunology, University of Oulu, Oulu, Finland
4Faculty of Medicine, University of Oulu, Oulu, Finland
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| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.8 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2019080223401 |
| Language: | English |
| Published: |
John Wiley & Sons,
2018
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| Publish Date: | 2019-08-02 |
| Description: |
AbstractBackground: Children whose 11th fetal week falls in pollen season (spring) reportedly have an increased risk of sensitization to food allergens. No such finding has been reported for pet allergens. Objective: The aim of the study was to (i) evaluate the incidence of pet (dog and cat) sensitization according to the season of the 11th fetal week and (ii) whether the association between pet exposure and respective sensitization is modified by the coincidence of the 11th fetal week with pollen season. Methods: The study population comprised all children (born between 2001 and 2006) in the province of South Karelia, Finland (N = 5920). Their data of immunoglobulin E antibodies and skin prick tests to pet allergens (N = 538) were collected from patient records and linked with questionnaire data on pet exposure. Results: The seasonal incidence peak of cat sensitization was observed in children whose 11th fetal week occurred in June (7.4%) and that of dog sensitization in April (3.8%) and June (4.7%). The relative rate (RR) for cat sensitization was 2.92 (95% CI 1.40‐6.08) in children with cat exposure alone, 8.53 (4.07‐17.86) in children with cat and fetal pollen exposures and 0.61 (0.20‐1.83) in children exposed to pollen alone, compared with children without these exposures. The respective RRs for dog sensitization were 2.17 (1.13‐4.19), 4.40 (2.19‐8.83) and 1.65 (0.77‐3.53). Conclusions and clinical relevance: Coincidence of the first fetal trimester with pollen season strengthens the association between pet exposure and respective sensitization. Pollen exposure at early pregnancy may deviate immune system towards Th2‐type reactivity promoting development of specific allergy in case allergen exposure occurred. Therefore, primary prevention of allergic diseases may need to begin during early pregnancy. see all
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| Series: |
Clinical & experimental allergy |
| ISSN: | 0954-7894 |
| ISSN-E: | 1365-2222 |
| ISSN-L: | 0954-7894 |
| Volume: | 48 |
| Issue: | 3 |
| Pages: | 306 - 316 |
| DOI: | 10.1111/cea.13067 |
| OADOI: | https://oadoi.org/10.1111/cea.13067 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics 3141 Health care science 3142 Public health care science, environmental and occupational health |
| Subjects: | |
| Funding: |
The data collection was mainly funded by the Social Insurance Institution of Finland and partly by EVO grants from the hospital districts of South Karelia, Northern Ostrobothnia and Pirkanmaa, by Lappeenranta City Council and personal grants to the principal investigator from the Finnish Cultural Foundation, South Karelia Regional fund, the Viipuri Tuberculosis Foundation, the Väinö and Laina Kivi Foundation, the Tyyni Tani Foundation, Kymenlaakson Terveyden Turva ry, the Allergy Foundation and the Medical Society of South Karelia. None of these organizations was involved in the design or execution of the study. The work of the principal investigator (KP) was funded in years 2012 to 2014 by University of Oulu and Lappeenranta University of Technology and in 2016 to 2017 by the Finnish Cultural Foundation, South Karelia Regional fund, and by the Finnish Cultural Foundation/Pekka and Jukka‐Pekka Lylykari's Fund. The work of the second author (PK) was supported by the research grants from the Alma and K.A. Snellman Foundation, the Finnish Medical Association, the Allergy Research Foundation and the Finnish Pediatric Research Foundation. The University of Oulu has provided working facilities for the study. None of the funding organizations was involved in the design or execution of the study. |
| Copyright information: |
© 2017 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Pyrhönen, K., Kulmala, P., & Näyhä, S. (2017). Coincidence of pollen season with the first fetal trimester together with early pet exposure is associated with sensitization to cat and dog allergens in early childhood: A Finnish population-based study. Clinical & Experimental Allergy, 48(3), 306–316. https://doi.org/10.1111/cea.13067, which has been published in final form at https://doi.org/10.1111/cea.13067. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |