University of Oulu

Juha Tuukkanen* and Miho Nakamura, “Hydroxyapatite as a Nanomaterial for Advanced Tissue Engineering and Drug Therapy”, Current Pharmaceutical Design (2017) 23: 3786.

Hydroxyapatite as a nanomaterial for advanced tissue engineering and drug therapy

Saved in:
Author: Tuukkanen, Juha1; Nakamura, Miho1,2
Organizations: 1Department of Anatomy and Cell Biology, Institute of Cancer and Translational Medicine, University of Oulu, Oulu, Finland
2Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
Persistent link:
Language: English
Published: Bentham Science, 2017
Publish Date: 2019-08-06


Hydroxyapatite (HAp) is a complicated ceramic material that varies between the way it appears in biological systems and how it is synthesized as various calcium phosphates. HAp varies in chemical composition of substituting atoms, crystallinity, grain size and electrical polarization. HAp can form solid to macro-, micro- and nanoporous structures. Also, particulate HAp can have highly porous structure. HAp can be used as coatings for metal implants in thicknesses from hundreds of microns down to hundreds of nanometers. Cotton wool-like HAp fibers can be electrospun compounded with polymers (or without) for tissue engineering (TE) scaffolds. This review describes the features of HAp that may be utilized further in developing novel applications. As a nanomaterial HAp has been applied for drug delivery. The adsorption of proteins and other compounds can be adjusted by modifying HAp composition, electrical polarization and wettability. Of special interest are the bisphosphonates that bind to HAp and thereby can be used to treat bone loss and also couple other drugs to the mineral. A new area for HAp constructs may appear in treating metallosis. HAp coating may function as a scavenger for the ions release from metal implants and thereby inhibit the adverse effects of the ion burden for the body. So far HAp is considered as safe biomaterial but nano HAp may insidiously possess adverse effects especially when ingested by cells and eliciting excess intracellular calcium. Thereby critical approach also for HAp biomaterials is of utmost importance.

see all

Series: Current pharmaceutical design
ISSN: 1381-6128
ISSN-E: 1873-4286
ISSN-L: 1381-6128
Volume: 27
Issue: 26
Pages: 3786 - 3793
DOI: 10.2174/1381612823666170609084016
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3111 Biomedicine
Copyright information: © 2017 Bentham Science Publishers. The Version of Record is available at: