University of Oulu

Casula, V. , Nissi, M. J., Podlipská, J. , Haapea, M. , Koski, J. M., Saarakkala, S. , Guermazi, A. , Lammentausta, E. and Nieminen, M. T. (2017), Elevated adiabatic T1ρ and T2ρ in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis: A preliminary study. J. Magn. Reson. Imaging, 46: 678-689. doi:10.1002/jmri.25616

Elevated adiabatic T₁ρ and T₁ρ in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis : a preliminary study

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Author: Casula, Victor1,2; Nissi, Mikko J.3,4; Podlipská, Jana1,5;
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
2Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
3Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
4Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland
5Infotech Oulu, University of Oulu, Oulu, Finland
6Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
7Department of Internal Medicine, Mikkeli Central Hospital, Mikkeli, Finland
8Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 2.4 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019080723606
Language: English
Published: , 2017
Publish Date: 2019-08-07
Description:

Abstract

Purpose: To evaluate adiabatic T₁ρ and T₂ρ of articular cartilage in symptomatic osteoarthritis (OA) patients and asymptomatic volunteers, and to determine their association with magnetic resonance imaging (MRI)‐based structural abnormalities in cartilage and bone.

Materials and Methods: A total of 24 subjects (age range: 50–68 years; 12 female) were enrolled, including 12 early OA patients and 12 volunteers with normal joint function. Patients and volunteers underwent 3T MRI. T₂ρ, adiabatic T₁ρ, and T₂ρ relaxation times of knee articular cartilage were measured. Proton density (PD)‐ and T₁‐weighted MR image series were also obtained and separately evaluated for morphological changes using the MRI OA Knee Scoring (MOAKS) system. Comparisons using the Mann–Whitney nonparametric test were performed after dividing the study participants according to physical symptoms as determined by Western Ontario and McMaster Universities (WOMAC) score or presence of cartilage lesions, bone marrow lesions, or osteophytes.

Results: Elevated adiabatic T₁ρ and T₂ρ relaxation times of articular cartilage were associated with cartilage loss (P = 0.024–0.047), physical symptoms (0.0068–0.035), and osteophytes (0.0039–0.027). Elevated adiabatic T₁ρ was also associated with bone marrow lesions (0.033).

Conclusion: Preliminary data suggest that elevated adiabatic T₁ρ and T₂ρ of cartilage are associated with morphological abnormalities of cartilage and bone, and thus may be applicable for in vivo OA research and diagnostics.

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Volume: 46
Issue: 3
Pages: 678 - 689
DOI: 10.1002/jmri.25616
OADOI: https://oadoi.org/10.1002/jmri.25616
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
T1p
T2p
Funding: Contract grant sponsor: Academy of Finland; contract grant numbers: 260321; 285909; 268378; 293970; Contract grant sponsor: Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland. The Center for Magnetic Resonance Research, University of Minnesota, is gratefully acknowledged for providing the adiabatic T1ρ and T2ρ sequences.
Academy of Finland Grant Number: 260321
285909
268378
293970
Detailed Information: 260321 (Academy of Finland Funding decision)
285909 (Academy of Finland Funding decision)
268378 (Academy of Finland Funding decision)
293970 (Academy of Finland Funding decision)
Copyright information: © 2017 International Society for Magnetic Resonance in Medicine. This is the peer reviewed version of the following article: Casula, V. , Nissi, M. J., Podlipská, J. , Haapea, M. , Koski, J. M., Saarakkala, S. , Guermazi, A. , Lammentausta, E. and Nieminen, M. T. (2017), Elevated adiabatic T1ρ and T2ρ in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis: A preliminary study. J. Magn. Reson. Imaging, 46: 678-689. doi:10.1002/jmri.25616, which has been published in final form at https://doi.org/10.1002/jmri.25616. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.