University of Oulu

Dremin, V, Kozlov, I, Volkov, M, et al. Dynamic evaluation of blood flow microcirculation by combined use of the laser Doppler flowmetry and high‐speed videocapillaroscopy methods. J. Biophotonics. 2019; 12:e201800317. https://doi.org/10.1002/jbio.201800317

Dynamic evaluation of blood flow microcirculation by combined use of the laser Doppler flowmetry and high-speed videocapillaroscopy methods

Saved in:
Author: Dremin, Viktor1,2; Kozlov, Igor1; Volkov, Mikhail3;
Organizations: 1Research & Development Center of Biomedical Photonics, Orel State University named after I.S. Turgenev, Orel, Russia
2Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
3Faculty of Applied Optics, ITMO University, St. Petersburg, Russia
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019081324015
Language: English
Published: John Wiley & Sons, 2019
Publish Date: 2020-01-12
Description:

Abstract

The dynamic light scattering methods are widely used in biomedical diagnostics involving evaluation of blood flow. However, there exist some difficulties in quantitative interpretation of backscattered light signals from the viewpoint of diagnostic information. This study considers the application of the high‐speed videocapillaroscopy (VCS) method that provides the direct measurement of the red blood cells (RBCs) velocity into a capillary. The VCS signal presents true oscillation nature of backscattered light caused by moving RBCs. Thus, the VCS signal can be assigned as a reference one with respect to more complicated signals like in laser Doppler flowmetry (LDF). An essential correlation between blood flow velocity oscillations in a separate human capillary and the integral perfusion estimate obtained by the LDF method has been found. The observation of blood flow by the VCS method during upper arm occlusion has shown emergence of the reverse blood flow effect in capillaries that corresponds to the biological zero signal in the LDF. The reverse blood flow effect has to be taken into account in interpretation of LDF signals.

see all

Series: Journal of biophotonics
ISSN: 1864-063X
ISSN-E: 1864-0648
ISSN-L: 1864-063X
Volume: 12
Issue: 6
Article number: e201800317
DOI: 10.1002/jbio.201800317
OADOI: https://oadoi.org/10.1002/jbio.201800317
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
Subjects:
Funding: This study was supported by the Russian Science Founda-tion under project No. 18-15-00201 (collection and processing of experimental data by the CWT) and Ministry of Science and Higher Education of the Russian Federation under project No. 8.2501.2017/4.6 (development of the experimental setup, processing and evaluation of the VCS experimental data). E.Z. kindly acknowledges for personal support from grant of Academy of Finland No. 318281.
Academy of Finland Grant Number: 318281
Detailed Information: 318281 (Academy of Finland Funding decision)
Copyright information: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Dremin, V, Kozlov, I, Volkov, M, et al. Dynamic evaluation of blood flow microcirculation by combined use of the laser Doppler flowmetry and high‐speed videocapillaroscopy methods. J. Biophotonics. 2019; 12:e201800317. https://doi.org/10.1002/jbio.201800317, which has been published in final form at https://doi.org/10.1002/jbio.201800317. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.