University of Oulu

Janne Lauri et al 2019 Mater. Res. Express 6 075333.

Effect of solvent lamination on roll-to-roll hot-embossed PMMA microchannels evaluated by optical coherence tomography

Saved in:
Author: Lauri, Janne1; Liedert, Christina2; Kokkonen, Annukka2;
Organizations: 1Optoelectronics and Measurement Techniques Unit, Faculty of Information Technology and Electrical Engineering, University of Oulu, PO Box 4500, FI-90014, Oulu, Finland
2VTT Technical Research Centre of Finland Ltd, Kaitoväylä 1, PO Box 1100, 90571 Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link:
Language: English
Published: IOP Publishing, 2019
Publish Date: 2020-04-24


Manufacturing of microfluidic based diagnostic devices requires small tolerances and uniform quality to guarantee reliable and repeatable test results. This work describes characterization of morphological changes that occur to a hot embossed PMMA microfluidic channel after solvent lamination with a PMMA lid. A non-contact cross-sectional analysis of the lidded microfluidic device was performed by optical coherence tomography (OCT). The solvent induced morphology change led to a porous structure in bottom corners of hot-embossed channels, which allowed a fluid to absorb in the material. The measurements of solvent diffusion showed faster diffusion rate at the corners of the channel, in which the accumulated stress during the embossing process was the highest. The stress profile was verified by simulation of von Mises stresses during a molding phase of a hot embossing process. The porous structure with increased fluid diffusion has an unwanted effect on bioassay result, e.g. when detection molecules leak into the substrate thus leading to unspecific signal on chip. OCT was found to be a valuable, non-destructive imaging method to monitor solvent diffusion process and lamination process quality.

see all

Series: Materials research express
ISSN: 2053-1591
ISSN-E: 2053-1591
ISSN-L: 2053-1591
Volume: 6
Issue: 7
Article number: 075333
DOI: 10.1088/2053-1591/ab11a7
Type of Publication: A1 Journal article – refereed
Field of Science: 216 Materials engineering
Funding: European Regional Development Fund (project: Development of mass manufacturing methods for highly integrated disposable rapid diagnostic platforms,A70245) is gratefully acknowledged for supporting this work. In addition, the contribution of the last author of this paper is financially supported by Academy of Finland’s 6Genesis Flagship (grant no. 318927).
Academy of Finland Grant Number: 318927
Detailed Information: 318927 (Academy of Finland Funding decision)
Copyright information: © 2019 IOP Publishing. This is the pre-peer reviewed version of the following article: Janne Lauri et al., Effect of solvent lamination on roll-to-roll hot-embossed PMMA microchannels evaluated by optical coherence tomography, Materials Research Express 6(7): 075333 (2019), which has been published in final form at DOI: 10.1088/2053-1591/aade7b. This article may be used for non-commercial purposes in accordance with IOP Publishing terms and conditions for use of self-archived versions.