Effect of solvent lamination on roll-to-roll hot-embossed PMMA microchannels evaluated by optical coherence tomography
|Author:||Lauri, Janne1; Liedert, Christina2; Kokkonen, Annukka2;|
1Optoelectronics and Measurement Techniques Unit, Faculty of Information Technology and Electrical Engineering, University of Oulu, PO Box 4500, FI-90014, Oulu, Finland
2VTT Technical Research Centre of Finland Ltd, Kaitoväylä 1, PO Box 1100, 90571 Oulu, Finland
3 Optoelectronics and Measurement Techniques Unit, Faculty of Information Technology and Electrical Engineering, University of Oulu, PO Box 4500, FI-90014, Oulu, Finland
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019081424168
|Publish Date:|| 2020-04-24
Manufacturing of microfluidic based diagnostic devices requires small tolerances and uniform quality to guarantee reliable and repeatable test results. This work describes characterization of morphological changes that occur to a hot embossed PMMA microfluidic channel after solvent lamination with a PMMA lid. A non-contact cross-sectional analysis of the lidded microfluidic device was performed by optical coherence tomography (OCT). The solvent induced morphology change led to a porous structure in bottom corners of hot-embossed channels, which allowed a fluid to absorb in the material. The measurements of solvent diffusion showed faster diffusion rate at the corners of the channel, in which the accumulated stress during the embossing process was the highest. The stress profile was verified by simulation of von Mises stresses during a molding phase of a hot embossing process. The porous structure with increased fluid diffusion has an unwanted effect on bioassay result, e.g. when detection molecules leak into the substrate thus leading to unspecific signal on chip. OCT was found to be a valuable, non-destructive imaging method to monitor solvent diffusion process and lamination process quality.
Materials research express
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
216 Materials engineering
European Regional Development Fund (project: Development of mass manufacturing methods for highly integrated disposable rapid diagnostic platforms,A70245) is gratefully acknowledged for supporting this work. In addition, the contribution of the last author of this paper is financially supported by Academy of Finland’s 6Genesis Flagship (grant no. 318927).
|Academy of Finland Grant Number:||
318927 (Academy of Finland Funding decision)
© 2019 IOP Publishing. This is the pre-peer reviewed version of the following article: Janne Lauri et al., Effect of solvent lamination on roll-to-roll hot-embossed PMMA microchannels evaluated by optical coherence tomography, Materials Research Express 6(7): 075333 (2019), which has been published in final form at DOI: 10.1088/2053-1591/aade7b. This article may be used for non-commercial purposes in accordance with IOP Publishing terms and conditions for use of self-archived versions.