University of Oulu

Pekka Pinola, Katri Puukka, Terhi T. Piltonen, Johanna Puurunen, Eszter Vanky, Inger Sundström-Poromaa, Elisabet Stener Victorin, Angelica Lindén Hirschberg, Pernille Ravn, Marianne Skovsager Andersen, Dorte Glintborg, Jan Roar Mellembakken, Aimo Ruokonen, Juha S. Tapanainen, Laure C. Morin-Papunen, Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life, Fertility and Sterility, Volume 107, Issue 3, 2017, Pages 788-795.e2, ISSN 0015-0282,

Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life

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Author: Pinola, Pekka1,2; Puukka, Katri2,3; Piltonen, Terhi T.1,2;
Organizations: 1Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland
2University of Oulu and Medical Research Center Oulu, Oulu, Finland
3Nordlab Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, Oulu, Finland
4Institute of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway
5Department of Obstetrics and Gynecology, St. Olav's University Hospital Trondheim, Trondheim, Norway
6Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
7Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
8Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden
9Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark
10Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
11Section of Reproductive Medicine, Department of Gynecology, Women's Division, Oslo University Hospital, Oslo, Norway
12Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
Persistent link:
Language: English
Published: Elsevier, 2017
Publish Date: 2019-08-15


Objective: To compare the metabolic profiles of normo- and hyperandrogenic women with polycystic ovary syndrome (PCOS) with those of control women at different ages during reproductive life.

Design: Case-control study.

Setting: Not applicable.

Patient(s): In all, 1,550 women with normoandrogenic (n = 686) or hyperandrogenic (n = 842) PCOS and 447 control women were divided into three age groups: <30, 30–39, and >39 years).

Interventions(s): None.

Main Outcome Measure(s): Body mass index (BMI), waist circumference, blood pressure, glucose, insulin, cholesterol, lipoproteins, triglycerides and high-sensitivity C-reactive protein.

Result(s): Both normo- and hyperandrogenic women with PCOS were more obese, especially abdominally. They had increased serum levels of insulin (fasting and in oral glucose tolerance tests), triglycerides, low-density lipoprotein, and total cholesterol, higher blood pressure, and lower high-density lipoprotein levels independently from BMI compared with the control population as early as from young adulthood until menopause. The prevalence of metabolic syndrome was two- to fivefold higher in women with PCOS compared with control women, depending on age and phenotype, and the highest prevalence was observed in hyperandrogenic women with PCOS at late reproductive age.

Conclusion(s): When evaluating metabolic risks in women with PCOS, androgenic status, especially abdominal obesity and age, should be taken into account, which would allow tailored management of the syndrome from early adulthood on.

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Series: Fertility and sterility
ISSN: 0015-0282
ISSN-E: 1556-5653
ISSN-L: 0015-0282
Volume: 107
Issue: 3
Pages: 788 - 795
Article number: 795.e2
DOI: 10.1016/j.fertnstert.2016.12.017
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Copyright information: © 2016 American Society for Reproductive Medicine, Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license