University of Oulu

A. Sdobnov, A. Bykov, A. Popov, I. Lihacova, A. Lihachev, J. Spigulis, and I. Meglinski "Combined multi-wavelength laser speckle contrast imaging and diffuse reflectance imaging for skin perfusion assessment", Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110751F (22 July 2019);

Combined multi-wavelength laser speckle contrast imaging and diffuse reflectance imaging for skin perfusion assessment

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Author: Sdobnov, A.1; Bykov, A.1; Popov, A.1;
Organizations: 1Univ. of Oulu (Finland)
2Univ. of Latvia (Latvia)
Format: abstract
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
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Language: English
Published: SPIE, 2019
Publish Date: 2019-08-16


Laser Speckle Contrast Imaging (LSCI) is a powerful low-cost method for visualization of flow, microcirculation and blood perfusion. Due to the fact that diseased and healthy tissues has different blood perfusion, LSCI can be a perspective tool for cancer diagnostics and discrimination between different types of tissues. Previously, multispectral diffuse reflectance imaging method for melanoma diagnostics has been introduced. In this work, multi-wavelength (532-, 655- and 850- nm) LSCI technique combined with hyperspectral camera and diffuse reflectance imaging method will be used for assessment of tissues with different skin perfusion properties. An in vivo experiment with occlusion in human finger was performed serving as a model of tissues with different perfusion properties. The proposed method still requires further development and improvements to become a real clinical laboratory tool for non-invasive skin cancer diagnostics

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Series: Proceedings of SPIE
ISSN: 0277-786X
ISSN-E: 1996-756X
ISSN-L: 0277-786X
Volume: 11075
Article number: 110751F
DOI: 10.1117/12.2526921
Host publication: Proceedings Volume 11075. European Conferences on Biomedical Optics, 23-27 June 2019 : Novel Biophotonics Techniques and Applications V
Host publication editor: Amelink, Arjen
Nadkarni, Seemantini K
Conference: European Conferences on Biomedical Optics
Field of Science: 114 Physical sciences
Funding: A.S was supported by Finnish Cultural Foundation (00180998). I.L. was supported by European Regional Development Fund project “Development and clinical validation of a novel cost effective multi-modal methodology for early diagnostics of skin cancers” (No., agreement No. A.B. and A.P. acknowledge support provided by the Academy of Finland (290596).
Academy of Finland Grant Number: 290596
Detailed Information: 290596 (Academy of Finland Funding decision)
Copyright information: © 2019 Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.