Ollila, M.-M. E., Kaikkonen, K., Järvelin, M.-R., Huikuri, H. V., Tapanainen, J. S., Franks, S., … Morin-Papunen, L. (2018). Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study. The Journal of Clinical Endocrinology & Metabolism, 104(4), 1221–1231. https://doi.org/10.1210/jc.2018-00570
Self-reported polycystic ovary syndrome is associated with hypertension : a Northern Finland Birth Cohort 1966 study
|Author:||Ollila, Meri-Maija E1; Kaikkonen, Kari2; Järvelin, Marjo-Riitta3,4,5,6;|
1Department of Obstetrics and Gynecology, University of Oulu and Oulu University Hospital, Medical Research Center, PEDEGO Research Unit, Oulu, Finland
2Division of Cardiology, Department of Clinical Medicine, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
3MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
4Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland Biocenter Oulu, University of Oulu, Oulu, Finland
5Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland
6Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, United Kingdom
7Research Unit of Internal Medicine, Medical Research Center, University Hospital of Oulu and University of Oulu, Oulu, Finland
8Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
|Online Access:||PDF Full Text (PDF, 0.3 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019082024795
|Publish Date:|| 2019-08-20
Context: Polycystic ovary syndrome (PCOS) is associated with many traditional cardiovascular disease risk factors, but it is unclear whether PCOS is an independent risk factor for hypertension.
Objective: To investigate in a population-based setup whether PCOS associates with the risk of hypertension independently of body mass index (BMI) and with cardiovascular manifestations.
Design: Cross-sectional assessments in the Northern Finland Birth Cohort 1966 at ages 31 and 46 years.
Setting: General community.
Participants: Women who reported both oligo/amenorrhea and hirsutism at age 31 years and/or a diagnosis of PCOS by age 46 years [self-reported PCOS (srPCOS), n = 279] and women without PCOS symptoms or diagnosis (n = 1577).
Main Outcome Measures: Blood pressure (BP), BMI, and cardiovascular manifestations.
Results: Use of antihypertensive medication was significantly more common in women with srPCOS. At age 31 years, women with srPCOS had significantly higher systolic BP (SBP) and diastolic BP (DBP) than control women (SBP: normal weight: 119.9 ± 13.2 vs 116.9 ± 11.4 mm Hg, P = 0.017; overweight/obese: 126.1 ± 14.3 vs 123.0 ± 11.9 mm Hg, P = 0.031; and DBP: normal weight: 75.5 ± 10.0 vs 72.4 ± 9.6 mm Hg, P = 0.003; overweight/obese: 80.7 ± 11.8 vs 78.0 ± 10.6 mm Hg, P = 0.031). At age 46 years, srPCOS was significantly associated with hypertension (adjusted odds ratio = 1.56; 95% CI, 1.14 to 2.13) independently of BMI and with higher cardiovascular morbidity (6.8% vs 3.4%, P = 0.011). Hypertensive srPCOS displayed consistent, unfavorable changes in cardiac structure and function compared with controls.
Conclusion: Women with srPCOS displayed higher BP compared with controls already at early age and srPCOS was associated with hypertension independently of overweight/obesity. srPCOS was associated with increased cardiovascular morbidity in premenopausal women, suggesting that cardiovascular disease risk factors should be screened and efficiently managed early enough in women with PCOS.
Journal of clinical endocrinology & metabolism
|Pages:||1221 - 1231|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
This work was supported by grants from the Finnish Medical Foundation, the North Ostrobothnia Regional Fund, Academy of Finland (project grants 315921, 104781, 120315, 129269, 1114194, 24300796, 295760), Center of Excellence in Complex Disease Genetics and SALVE, the Sigrid Juselius Foundation, University Hospital Oulu and University of Oulu (75617), Medical Research Center Oulu, National Institute for Health Research (UK), Genesis Research Trust (UK), NHLBI grant 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01), NIH/NIMH (5R01MH63706:02), ENGAGE project and grant agreement HEALTH-F4-2007-201413, EU FP7 EurHEALTHAgeing-277849 from the European Commission and the Medical Research Council (UK) (G0500539, G0600705, G1002319, G0802782, PrevMetSyn/SALVE), and the MRC, Centenary Early Career Award.
|EU Grant Number:||
(277849) EURHEALTHAGEING - European ResearcH on DevElopmentAL, BirtH and Genetic Determinants of Ageing
|Academy of Finland Grant Number:||
315921 (Academy of Finland Funding decision)
129269 (Academy of Finland Funding decision)
114194 (Academy of Finland Funding decision)
© 2019 Endocrine Society. This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Clinical Endocrinology & Metabolism following peer review. The version of record Ollila, M.-M. E., Kaikkonen, K., Järvelin, M.-R., Huikuri, H. V., Tapanainen, J. S., Franks, S., … Morin-Papunen, L. (2018). Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study. The Journal of Clinical Endocrinology & Metabolism, 104(4), 1221–1231. https://doi.org/10.1210/jc.2018-00570 is available online at: https://doi.org/10.1210/jc.2018-00570.