University of Oulu

Irina Mizeva, Irina Makovik, Andrey Dunaev, Alexander Krupatkin, Igor Meglinski, "Analysis of skin blood microflow oscillations in patients with rheumatic diseases," Journal of Biomedical Optics 22(7), 070501 (13 July 2017).

Analysis of skin blood microflow oscillations in patients with rheumatic diseases

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Author: Mizeva, Irina1; Makovik, Irina2; Dunaev, Andrey2;
Organizations: 1Institute of Continuous Media Mechanics, Perm, Russia
2Priorov Central Scientific Research Institute of Traumatology and Orthopedics, Moscow, Russia
3University of Oulu, Opto-Electronics and Measurement Techniques, Oulu, Finland
4Institute of Biology, Irkutsk State University, Irkutsk, Russia
5ITMO University, St. Petersburg, Russia
6Tomsk State University, Interdisciplinary Laboratory of Biophotonics, Tomsk, Russia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: SPIE, 2017
Publish Date: 2019-08-23


Laser Doppler flowmetry (LDF) has been applied for the assessment of variation in blood microflows in patients with rheumatic diseases and healthy volunteers. Oscillations of peripheral blood microcirculation observed by LDF have been analyzed utilizing a wavelet transform. A higher amplitude of blood microflow oscillations has been observed in a high frequency band (over 0.1 Hz) in patients with rheumatic diseases. Oscillations in the high frequency band decreased in healthy volunteers in response to the cold pressor test, whereas lower frequency pulsations prevailed in patients with rheumatic diseases. A higher perfusion rate at normal conditions was observed in patients, and a weaker response to cold stimulation was observed in healthy volunteers. Analysis of blood microflow oscillations has a high potential for evaluation of mechanisms of blood flow regulation and diagnosis of vascular abnormalities associated with rheumatic diseases.

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Series: Journal of biomedical optics
ISSN: 1083-3668
ISSN-E: 1560-2281
ISSN-L: 1083-3668
Volume: 22
Issue: 7
Article number: 070501
DOI: 10.1117/1.JBO.22.7.070501
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
Funding: The work was supported by the Russian Foundation for basic research RFBR (projects no. 17-41-590560). Professor Meglinski also acknowledges partial support provided by the Russian Science Foundation (project no. 15-14-10008).
Copyright information: © 2017 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in t his paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.