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Väyrynen, J. P., Väyrynen, S. A., Sirniö, P., Minkkinen, I., Klintrup, K., Karhu, T., … Mäkinen, M. J. (2019). Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer. Journal of Translational Medicine, 17(1). https://doi.org/10.1186/s12967-019-1950-z

Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer

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Author: Väyrynen, Juha P.1,2,3; Väyrynen, Sara A.1,2,4; Sirniö, Päivi1,2;
Organizations: 1Cancer and Translational Medicine Research Unit, University of Oulu, POB 5000, 90014, Oulu, Finland
2Department of Pathology, Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029, Oulu, Finland
3Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Ave, Boston, MA, 02215, USA
4Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Ave, Boston, MA, 02215, USA
5Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu, POB 5000, 90014, Oulu, Finland
6Department of Surgery, Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029, Oulu, Finland
7Research Unit of Biomedicine and Biocenter of Oulu, University of Oulu, POB 5000, 90014, Oulu, Finland
8Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029, Oulu, Finland
9Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572, Poznan, Poland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.7 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019082325278
Language: English
Published: Springer Nature, 2019
Publish Date: 2019-08-23
Description:

Abstract

Background: Platelets not only contribute to hemostasis but also to the regulation of inflammatory reactions and cancer pathogenesis. We hypothesized that blood platelet count would be associated with systemic inflammation, the densities of tumor infiltrating immune cells, and survival in colorectal cancer (CRC), and these relationships could be altered by aspirin use.

Methods: We measured blood platelet count in a cohort of 356 CRC patients and analyzed its relationships with tumor and patient characteristics including aspirin use, markers of systemic inflammation (modified Glasgow Prognostic Score, mGPS; serum levels of CRP, albumin, and 13 cytokines), blood hemoglobin levels, five types of tumor infiltrating immune cells (CD3, CD8, FoxP3, Neutrophil elastase, mast cell tryptase), and survival.

Results: Platelet count inversely correlated with blood hemoglobin levels (p < 0.001) and positively correlated with serum levels of CRP and multiple cytokines including IL-1RA, IL-4, IL-6, IL-7, IL-8, IL-12, IFNγ, and PDGF-BB (p < 0.001 for all), while aspirin use was not associated with the levels of systemic inflammatory markers. High platelet count was also associated with high mGPS (p < 0.001) but did not show statistically significant multivariable adjusted associations with the densities of tumor infiltrating immune cells. Higher platelet counts were observed in higher tumor stage (p < 0.001), but platelet count or aspirin use were not associated with patient survival.

Conclusions: High platelet count is associated with systemic inflammation in CRC. This study could not demonstrate statistically significant associations between platelet count, aspirin use, and the densities of tumor infiltrating immune cells.

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Series: Journal of translational medicine
ISSN: 1479-5876
ISSN-E: 1479-5876
ISSN-L: 1479-5876
Volume: 17
Article number: 199
DOI: 10.1186/s12967-019-1950-z
OADOI: https://oadoi.org/10.1186/s12967-019-1950-z
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Subjects:
Aspirin
CRP
Colorectal cancer
Cytokine
Inflammation
Platelet
Prognosis
Thrombocytosis
Article
Copyright information: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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