University of Oulu

Ollila, M.-M. E., Piltonen, T., Puukka, K., Ruokonen, A., Järvelin, M.-R., Tapanainen, J. S., … Morin-Papunen, L. (2016). Weight Gain and Dyslipidemia in Early Adulthood Associate With Polycystic Ovary Syndrome: Prospective Cohort Study. The Journal of Clinical Endocrinology & Metabolism, 101(2), 739–747. https://doi.org/10.1210/jc.2015-3543

Weight gain and dyslipidemia in early adulthood associate with polycystic ovary syndrome : prospective cohort study

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Author: Ollila, Meri-Maija E.1; Piltonen, Terhi1; Puukka, Katri2;
Organizations: 1Department of Obstetrics and Gynecology (M.-M.E.O., T.P., J.S.T., L.M.-P.), University Hospital of Oulu, University of Oulu, Medical Research Center Oulu and PEDEGO (Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology) Research Unit, Oulu, FI-90029, Finland
2NordLab Oulu (K.P., A.R.), Department of Clinical Chemistry, University Hospital of Oulu, University of Oulu and Medical Research Center Oulu, Oulu, FI-90029, Finland
3Department of Epidemiology and Biostatistics (M.-R.J.), Medical Research Council-PHE (Public Health England) Centre for Environment & Health, School of Public Health, Imperial College London, United Kingdom W2 1PG
4Center for Life Course Epidemiology (M.-R.J.), Faculty of Medicine, University of Oulu, Oulu, FI-90014, Finland
5Biocenter Oulu (M.-R.J.), University of Oulu, Oulu, FI-90014, Finland
6Unit of Primary Care (M.-R.J.), University Hospital of Oulu, Oulu, FI-90220, Finland
7Department of Obstetrics and Gynecology (J.S.T.), University of Helsinki and Helsinki University Hospital, Helsinki, FI-00014, Finland
8Institute of Reproductive and Developmental Biology (S.F.), Imperial College London, United Kingdom W12 ONN
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019082625523
Language: English
Published: Endocrine society, 2016
Publish Date: 2019-08-26
Description:

Abstract

Context: Obesity affects the majority of women with polycystic ovary syndrome (PCOS), but previous studies are inconsistent about the prevalence of obesity and the importance of weight gain in the development of the syndrome.

Objective: Our objective was to explore the association between weight, weight gain, hyperandrogenism, and PCOS from adolescence to late adulthood.

Design: The study includes a prospective Northern Finland Birth Cohort 1966 study including 5889 females born in 1966 and followed at the ages of 14, 31, and 46 years.Setting: The setting was the general community.

Participants: Women presenting both oligo/amenorrhea (OA) and hirsutism (H) at age 31 (N = 125) or with formally diagnosed PCOS by age 46 (N = 181) were compared with women without PCOS symptoms or diagnosis (n = 1577).

Interventions: None.

Main Outcome Measures: Body mass index (BMI), weight change through life, waist circumference, Free Androgen Index, lipids, glucose, insulin, high-sensitivity C-reactive protein, homeostatic model assessment for insulin resistance, and PCOS.

Results: Women with OA+H at age 31 or diagnosis of PCOS by age 46 had the highest BMI at all ages compared with the controls. Increase of BMI between ages 14 and 31, but not between 31 and 46, was greater in women with isolated OA (P = .006), OA+H (P = .001), and diagnosis of PCOS (P = .001) compared with controls. In the multivariate analysis, PCOS was significantly associated with BMI at all ages (BMI at age 31: odds ratio [OR] = 1.05 [95% confidence interval (CI), 1.00–1.10], Free Androgen Index (OR = 1.08 [95% CI, 1.03–1.14]), serum levels of insulin (OR = 1.05 [95% CI, 1.00–1.09]), and triglycerides (OR = 1.48 [95% CI, 1.08–2.03]).

Conclusions: Symptoms or diagnosis of PCOS are associated with dyslipidemia, hyperandrogenemia, and significantly increased weight gain, especially in early adulthood. This observation is important because it may identify a sensitive time period when weight gain plays a crucial role in the emergence of PCOS and when preventive actions against metabolic and cardiovascular diseases should be implemented.

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Series: Journal of clinical endocrinology & metabolism
ISSN: 0021-972X
ISSN-E: 1945-7197
ISSN-L: 0021-972X
Volume: 101
Issue: 2
Pages: 739 - 747
DOI: 10.1210/jc.2015-3543
OADOI: https://oadoi.org/10.1210/jc.2015-3543
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Copyright information: © 2016 by the Endocrine Society. This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of clinical endocrinology and metabolism following peer review. The version of record Ollila, M.-M. E., Piltonen, T., Puukka, K., Ruokonen, A., Järvelin, M.-R., Tapanainen, J. S., … Morin-Papunen, L. (2016). Weight Gain and Dyslipidemia in Early Adulthood Associate With Polycystic Ovary Syndrome: Prospective Cohort Study. The Journal of Clinical Endocrinology & Metabolism, 101(2), 739–747. https://doi.org/10.1210/jc.2015-3543 is available online at: https://doi.org/10.1210/jc.2015-3543.