University of Oulu

Tejesvi, M. V., Nissi, R., Saravesi, K., Pirttilä, A. M., Markkola, A., Talvensaari-Mattila, A., & Ruotsalainen, A. L. (2019). Association of prevalent vaginal microbiome of mother with occurrence of type I diabetes in child. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-018-37467-w

Association of prevalent vaginal microbiome of mother with occurrence of type I diabetes in child

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Author: Tejesvi, Mysore V.1,2; Nissi , Ritva3; Saravesi, Karita1;
Organizations: 1Department of Ecology and Genetics, PO Box 3000, University of Oulu, FI-90014 Oulu, Finland
2Chain Antimicrobials Ltd, Teknologiantie 2, FI-90590, Oulu, Finland
3Department of Obstetrics and Gynecology, PO Box 5000, Oulu University Hospital, FI-90014, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019090526912
Language: English
Published: Springer Nature, 2019
Publish Date: 2019-09-05
Description:

Abstract

Type I diabetes (T1D) is a rapidly increasing autoimmune disease especially in the Western countries and poses a serious global health problem. Incidence of T1D cannot be fully explained by genetic background, and environmental factors have been assumed to play a role. Environmental conditions and composition of human microbiome have been found to correlate with the incidence of T1D. We asked whether mothers’ prevalent vaginal microbiome could correlate with the incidence of T1D in child. To test this hypothesis, we collected samples of vaginal microbiomes from eight mothers that had at least one child with T1D (child age maximum of 11 years at the time of sampling), born with a vaginal delivery. Eight control mothers had child/children with vaginal delivery and no diabetic child/children. The microbiomes were studied by using 16S rRNA Ion Torrent high throughput sequencing. We found that composition of total and Lactobacillus microbiome was altered, and saw an indication that diversity of vaginal microbiomes of the mothers with a diabetic child could be higher. Based on these pilot observations, we strongly encourage a larger population study to verify whether mother vaginal microbiome diversity and composition are linked to the prevalence of T1D in children.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 9
Article number: 959
DOI: 10.1038/s41598-018-37467-w
OADOI: https://oadoi.org/10.1038/s41598-018-37467-w
Type of Publication: A1 Journal article – refereed
Field of Science: 1183 Plant biology, microbiology, virology
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
1181 Ecology, evolutionary biology
Subjects:
Funding: The project was funded by Academy of Finland (project #138309 to AM) and K59780 (to A.T.-M.).
Academy of Finland Grant Number: 138309
Detailed Information: 138309 (Academy of Finland Funding decision)
Copyright information: © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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