Kati Mäkelä, Hely Ollila, Eva Sutinen, Vesa Vuorinen, Emilia Peltola, Riitta Kaarteenaho, Marjukka Myllärniemi, Inorganic particulate matter in the lung tissue of idiopathic pulmonary fibrosis patients reflects population density and fine particle levels, Annals of Diagnostic Pathology, Volume 40, 2019, Pages 136-142, ISSN 1092-9134, https://doi.org/10.1016/j.anndiagpath.2019.04.011
Inorganic particulate matter in the lung tissue of idiopathic pulmonary fibrosis patients reflects population density and fine particle levels
|Author:||Mäkelä, Kati1; Ollila, Hely1; Sutinen, Eva1;|
1Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
2Department of Electrical Engineering and Automation, School of Electrical Engineering, Aalto University, Espoo, Finland
3 Research Unit of Internal Medicine, University of Oulu and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 0.9 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019091227882
|Publish Date:|| 2019-09-12
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with a dismal prognosis and an unknown etiology. Inorganic dust is a known risk factor, and air pollution seems to affect disease progression. We aimed to investigate inorganic particulate matter in IPF lung tissue samples. Using polarizing light microscopy, we examined coal dust pigment and inorganic particulate matter in 73 lung tissue samples from the FinnishIPF registry. We scored the amount of coal dust pigment and particulate matter from 0 to 5. Using energy dispersive spectrometry with a scanning electron microscope, we conducted an elemental analysis of six IPF lung tissue samples. We compared the results to the registry data, and to the population density and air quality data. To compare categorical data, we used Fisher’s exact test; we estimated the survival of the patients with Kaplan-Meier curves. We found inorganic particulate matter in all samples in varying amounts. Samples from the southern regions of Finland, where population density and fine particle levels are high, more often had particulate matter scores from 3 to 5 than samples from the northern regions (31/50, 62.0% vs. 7/23, 30.4%, p = 0.02). The highest particulate matter scores of 4 and 5 (n = 15) associated with a known exposure to inorganic dust (p = 0.004). An association between particulate matter in the lung tissue of IPF patients and exposure to air pollution may exist.
Annals of diagnostic pathology
|Pages:||136 - 142|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This work was supported by Foundation of the Finnish Anti-Tuberculosis Association, the Research Foundation of the Pulmonary Diseases, the Väinö and Laina Kivi Foundation, the University of Helsinki, and the Biomedicum Helsinki Foundation.
© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).