University of Oulu

Kati Mäkelä, Hely Ollila, Eva Sutinen, Vesa Vuorinen, Emilia Peltola, Riitta Kaarteenaho, Marjukka Myllärniemi, Inorganic particulate matter in the lung tissue of idiopathic pulmonary fibrosis patients reflects population density and fine particle levels, Annals of Diagnostic Pathology, Volume 40, 2019, Pages 136-142, ISSN 1092-9134, https://doi.org/10.1016/j.anndiagpath.2019.04.011

Inorganic particulate matter in the lung tissue of idiopathic pulmonary fibrosis patients reflects population density and fine particle levels

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Author: Mäkelä, Kati1; Ollila, Hely1; Sutinen, Eva1;
Organizations: 1Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
2Department of Electrical Engineering and Automation, School of Electrical Engineering, Aalto University, Espoo, Finland
3 Research Unit of Internal Medicine, University of Oulu and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019091227882
Language: English
Published: Elsevier, 2019
Publish Date: 2019-09-12
Description:

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with a dismal prognosis and an unknown etiology. Inorganic dust is a known risk factor, and air pollution seems to affect disease progression. We aimed to investigate inorganic particulate matter in IPF lung tissue samples. Using polarizing light microscopy, we examined coal dust pigment and inorganic particulate matter in 73 lung tissue samples from the FinnishIPF registry. We scored the amount of coal dust pigment and particulate matter from 0 to 5. Using energy dispersive spectrometry with a scanning electron microscope, we conducted an elemental analysis of six IPF lung tissue samples. We compared the results to the registry data, and to the population density and air quality data. To compare categorical data, we used Fisher’s exact test; we estimated the survival of the patients with Kaplan-Meier curves. We found inorganic particulate matter in all samples in varying amounts. Samples from the southern regions of Finland, where population density and fine particle levels are high, more often had particulate matter scores from 3 to 5 than samples from the northern regions (31/50, 62.0% vs. 7/23, 30.4%, p = 0.02). The highest particulate matter scores of 4 and 5 (n = 15) associated with a known exposure to inorganic dust (p = 0.004). An association between particulate matter in the lung tissue of IPF patients and exposure to air pollution may exist.

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Series: Annals of diagnostic pathology
ISSN: 1092-9134
ISSN-E: 1532-8198
ISSN-L: 1092-9134
Volume: 40
Pages: 136 - 142
DOI: 10.1016/j.anndiagpath.2019.04.011
OADOI: https://oadoi.org/10.1016/j.anndiagpath.2019.04.011
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Subjects:
Funding: This work was supported by Foundation of the Finnish Anti-Tuberculosis Association, the Research Foundation of the Pulmonary Diseases, the Väinö and Laina Kivi Foundation, the University of Helsinki, and the Biomedicum Helsinki Foundation.
Copyright information: © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
  https://creativecommons.org/licenses/by-nc-nd/4.0/