University of Oulu

Toni Myllyaho, Virva Siira, Karl-Erik Wahlberg, Helinä Hakko, Kristian Läksy, Riikka Roisko, Mika Niemelä, Sami Räsänen, Interaction of genetic vulnerability to schizophrenia and family functioning in adopted-away offspring of mothers with schizophrenia, Psychiatry Research, Volume 278, 2019, Pages 205-212, -iSSN 0165-1781, https://doi.org/10.1016/j.psychres.2019.06.017

Interaction of genetic vulnerability to schizophrenia and family functioning in adopted-away offspring of mothers with schizophrenia

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Author: Myllyaho, Toni1; Siira, Virva2; Wahlberg, Karl-Erik1;
Organizations: 1Faculty of Medicine, Department of Psychiatry, University of Oulu, P.O. Box 5000, Oulu 90014, Finland
2Faculty of Education, University of Oulu, P.O. Box 2000, Oulu 90014, Finland
3Department of Psychiatry, Oulu University Hospital, P.O. Box 26, Oulu 90029, Finland
4Social Security Institute of Finland (SSI), Helsinki, Finland
5Department of Medicine, Center for Life Course Health Research, University of Oulu, P.O. Box 5000, Oulu 90014, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019091227939
Language: English
Published: Elsevier, 2019
Publish Date: 2020-06-13
Description:

Abstract

Objective: The aim of this study was to examine the association of family functioning to psychiatric disorders of adoptees with and without genetic vulnerability to schizophrenia.

Methods: The data is based on the Finnish Adoptive Family Study of Schizophrenia. The study sample consisted of 346 adoptive families, of which 175 adoptees had high (HR) and 171 low (LR) genetic risk for schizophrenia. DSM-III-R was used for diagnostic criteria. Family functioning was assessed using the Global Family Ratings. Childhood adversities covered early parental divorce and death occurring before 18 years of age of the adoptees.

Results: Approximately two thirds of the adoptees had lived in families with mildly dysfunctional processes (30%) or dysfunctional processes (28.4%). An increased likelihood for psychiatric disorders of the adoptees was related to dysfunctional family processes both in HR (OR = 4.8, 95% CI 2–11.4) and LR (OR = 2.6, 95% CI 1.1–6.3) adoptees, but not to early parental death or divorce.

Conclusions: The risk for psychiatric disorders was increased for adoptees in families with dysfunctional processes, especially for those adoptees with genetic vulnerability to schizophrenia. These results emphasize the importance of policies and practices that aim to strengthen and support family functioning.

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Series: Psychiatry research
ISSN: 0165-1781
ISSN-E: 1872-7123
ISSN-L: 0165-1781
Volume: 278
Pages: 205 - 212
DOI: 10.1016/j.psychres.2019.06.017
OADOI: https://oadoi.org/10.1016/j.psychres.2019.06.017
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Subjects:
Funding: This study was supported by Oulu University Hospital.
Copyright information: © 2019 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
  https://creativecommons.org/licenses/by-nc-nd/4.0/