University of Oulu

Timo Liimatainen, Hanne Laakso, Djaudat Idiyatullin, Silvia Mangia, Shalom Michaeli, Capturing exchange using periodic radiofrequency irradiation, Journal of Magnetic Resonance, Volume 296, 2018, Pages 79-84, ISSN 1090-7807,

Capturing exchange using periodic radiofrequency irradiation

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Author: Liimatainen, Timo1,2,3; Laakso, Hanne3; Idiyatullin, Djaudat4;
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
2Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
3A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
4Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
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Language: English
Published: Elsevier, 2018
Publish Date: 2020-09-05


The dynamics of spin system coupled by chemical exchange between two sites with different chemical shifts during periodic radiofrequency (RF) irradiation was here investigated. When the instantaneous π-flip of effective frequency during the course of frequency sweep was applied, a significant increase of exchange-induced relaxation rate constants was observed for small tip angle of magnetization in the laboratory frame of reference. This increase of the rate constants corresponds to the side bands generated by the periodic irradiation during the RF pulses. The exchange-induced relaxation rate constants depend on the exchange conditions, the RF power and the irradiation period. The described phenomenon promises applications for studying protein dynamics and for generating exchange specific relaxation contrasts in MRI.

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Series: Journal of magnetic resonance
ISSN: 1090-7807
ISSN-E: 1096-0856
ISSN-L: 1090-7807
Volume: 296
Pages: 79 - 84
DOI: 10.1016/j.jmr.2018.09.001
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
Funding: The authors would like to thank following funding sources for financial support Instrumentarium Science Foundation (HL), EUH2020 Marie Skłodowska RISE project #691110 (MICROBRADAM), Academy of Finland grants #275453 and #298007, NIH grants U01-NS103569, 1R01AG055591, BTRC, P41 EB015894, P30NS057091. SM was supported by Fulbright-Saastamoinen Foundation Grant in Health and Environmental Science.
Copyright information: © 2018 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license