University of Oulu

Isojärvi, H., Keinänen-Kiukaanniemi, S., Kallio, M., Kaikkonen, K., Jämsä, T., Korpelainen, J., & Korpelainen, R. (2017). Association of Insulin and Cholesterol Levels With Peripheral Nervous System Function in Overweight Adults. Journal of Clinical Neurophysiology, 34(6), 492–496. https://doi.org/10.1097/wnp.0000000000000425

Association of insulin and cholesterol levels with peripheral nervous system function in overweight adults : a 3-year follow-up

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Author: Isojärvi, Henri1,2; Keinänen-Kiukaanniemi, Sirkka1,3,4; Kallio, Mika2,3,5;
Organizations: 1Center for Life Course Health Research, University of Oulu, Oulu, Finland
2Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
3Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
4Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland
5Department of Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland
6Department of Sports and Exercise Medicine, Oulu Deaconess Institute, Oulu, Finland
7Department of Diagnostic Imaging, Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019091628294
Language: English
Published: Wolters Kluwer, 2017
Publish Date: 2019-09-16
Description:

Abstract

Purpose: The purpose of this prospective 3-year follow-up was to investigate the association of glucose, insulin, and cholesterol levels with peripheral nervous system function in overweight and obese subjects.

Methods: Forty nondiabetic overweight and obese adults were enrolled, of whom 29 completed the follow-up. Peripheral nervous system function was measured and defined by conduction studies of the peroneal motor nerve and the radial, sural, and medial plantar sensory nerves. Serum insulin and glucose levels were determined with an oral glucose tolerance test, and cholesterol levels were measured. The measurements were performed at baseline and after 3 years.

Results: The change in serum insulin level at 120 minutes after an oral glucose tolerance test was positively associated with changes in peroneal nerve conduction velocities and F-wave mean, sural nerve conduction and medial plantar nerve conduction velocities. Action potential amplitudes decreased consistently and significantly in all sensory nerves.

Conclusions: The change in serum insulin level at 120 minutes appears to be positively associated with changes in nerve conduction velocities more than 3 years but not with nerve action potential amplitudes. Significant decreases in the action potential amplitudes of all sensory nerves suggest that such changes might be the earliest detectable sign of damage to the peripheral nervous system in overweight and obese people without type 2 diabetes.

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Series: Journal of clinical neurophysiology
ISSN: 0736-0258
ISSN-E: 1537-1603
ISSN-L: 0736-0258
Volume: 34
Issue: 6
Pages: 492 - 496
DOI: 10.1097/WNP.0000000000000425
OADOI: https://oadoi.org/10.1097/WNP.0000000000000425
Type of Publication: A1 Journal article – refereed
Field of Science: 3112 Neurosciences
217 Medical engineering
Subjects:
Copyright information: © 2017 by the American Clinical Neurophysiology Society. The Version of Record can be found online at: http://dx.doi.org/10.1097/WNP.0000000000000425.