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ICU-treated influenza A(H1N1) pdm09 infections more severe post pandemic than during 2009 pandemic : a retrospective analysis |
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| Author: | Ylipalosaari, Pekka1; Ala-Kokko, Tero I.2,3; Laurila, Jouko2,3; |
| Organizations: |
1Department of Infection Control, Oulu University Hospital, Box 21, FIN-90029, Oulu, OYS, Finland 2Department of Anesthesiology, Division of Intensive Care, Oulu University Hospital, FIN-90029, Oulu, OYS, Finland 3Medical Research Center, Research Group of Surgery, Anesthesiology and Intensive Care, University of Oulu, Oulu, Finland
4Department of Radiology, Oulu University Hospital, FIN-90029, Oulu, OYS, Finland
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| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.5 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2019091728447 |
| Language: | English |
| Published: |
Springer Nature,
2017
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| Publish Date: | 2019-09-17 |
| Description: |
AbstractBackground: We compared in a single mixed intensive care unit (ICU) patients with influenza A(H1N1) pdm09 between pandemic and postpandemic periods. Methods: Retrospective analysis of prospectively collected data in 2009–2016. Data are expressed as median (25th–75th percentile) or number (percentile). Results: Seventy-six influenza A(H1N1) pdm09 patients were admitted to the ICU: 16 during the pandemic period and 60 during the postpandemic period. Postpandemic patients were significantly older (60 years vs. 43 years, p < 0.001) and less likely to have epilepsy or other neurological diseases compared with pandemic patients (5 [8.3%] vs. 6 [38%], respectively; p = 0.009). Postpandemic patients were more likely than pandemic patients to have cardiovascular disease (24 [40%] vs. 1 [6%], respectively; p = 0.015), and they had higher scores on APACHE II (17 [13–22] vs. 14 [10–17], p = 0.002) and SAPS II (40 [31–51] vs. 31 [25–35], p = 0.002) upon admission to the ICU. Postpandemic patients had higher maximal SOFA score (9 [5–12] vs. 5 [4–9], respectively; p = 0.03) during their ICU stay. Postpandemic patients had more often septic shock (40 [66.7%] vs. 8 [50.0%], p = 0.042), and longer median hospital stays (15.0 vs. 8.0 days, respectively; p = 0.006). During 2015–2016, only 18% of the ICU- treated patients had received seasonal influenza vaccination. Conclusions: Postpandemic ICU-treated A(H1N1) pdm09 influenza patients were older and developed more often septic shock and had longer hospital stays than influenza patients during the 2009 pandemic. see all
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| Series: |
BMC infectious diseases |
| ISSN: | 1471-2334 |
| ISSN-E: | 1471-2334 |
| ISSN-L: | 1471-2334 |
| Volume: | 17 |
| Article number: | 728 |
| DOI: | 10.1186/s12879-017-2829-3 |
| OADOI: | https://oadoi.org/10.1186/s12879-017-2829-3 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3111 Biomedicine |
| Subjects: | |
| Copyright information: |
© The Authors 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
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https://creativecommons.org/licenses/by/4.0/ |