Ylipalosaari, P., Ala-Kokko, T. I., Laurila, J., Ahvenjärvi, L., & Syrjälä, H. (2017). ICU-treated influenza A(H1N1) pdm09 infections more severe post pandemic than during 2009 pandemic: a retrospective analysis. BMC Infectious Diseases, 17(1). https://doi.org/10.1186/s12879-017-2829-3
ICU-treated influenza A(H1N1) pdm09 infections more severe post pandemic than during 2009 pandemic : a retrospective analysis
|Author:||Ylipalosaari, Pekka1; Ala-Kokko, Tero I.2,3; Laurila, Jouko2,3;|
1Department of Infection Control, Oulu University Hospital, Box 21, FIN-90029, Oulu, OYS, Finland
2Department of Anesthesiology, Division of Intensive Care, Oulu University Hospital, FIN-90029, Oulu, OYS, Finland
3Medical Research Center, Research Group of Surgery, Anesthesiology and Intensive Care, University of Oulu, Oulu, Finland
4Department of Radiology, Oulu University Hospital, FIN-90029, Oulu, OYS, Finland
|Online Access:||PDF Full Text (PDF, 0.5 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019091728447
|Publish Date:|| 2019-09-17
Background: We compared in a single mixed intensive care unit (ICU) patients with influenza A(H1N1) pdm09 between pandemic and postpandemic periods.
Methods: Retrospective analysis of prospectively collected data in 2009–2016. Data are expressed as median (25th–75th percentile) or number (percentile).
Results: Seventy-six influenza A(H1N1) pdm09 patients were admitted to the ICU: 16 during the pandemic period and 60 during the postpandemic period. Postpandemic patients were significantly older (60 years vs. 43 years, p < 0.001) and less likely to have epilepsy or other neurological diseases compared with pandemic patients (5 [8.3%] vs. 6 [38%], respectively; p = 0.009). Postpandemic patients were more likely than pandemic patients to have cardiovascular disease (24 [40%] vs. 1 [6%], respectively; p = 0.015), and they had higher scores on APACHE II (17 [13–22] vs. 14 [10–17], p = 0.002) and SAPS II (40 [31–51] vs. 31 [25–35], p = 0.002) upon admission to the ICU. Postpandemic patients had higher maximal SOFA score (9 [5–12] vs. 5 [4–9], respectively; p = 0.03) during their ICU stay. Postpandemic patients had more often septic shock (40 [66.7%] vs. 8 [50.0%], p = 0.042), and longer median hospital stays (15.0 vs. 8.0 days, respectively; p = 0.006). During 2015–2016, only 18% of the ICU- treated patients had received seasonal influenza vaccination.
Conclusions: Postpandemic ICU-treated A(H1N1) pdm09 influenza patients were older and developed more often septic shock and had longer hospital stays than influenza patients during the 2009 pandemic.
BMC infectious diseases
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
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