University of Oulu

Ragnheidur Valdimarsdottir, Heiddis Valgeirsdottir, Anna-Karin Wikström, Theodora Kunovac Kallak, Evangelia Elenis, Ove Axelsson, Kumari Ubhayasekhera, Jonas Bergquist, Terhi T Piltonen, Pascal Pigny, Paolo Giacobini, Inger Sundström Poromaa, Pregnancy and neonatal complications in women with polycystic ovary syndrome in relation to second-trimester anti-Müllerian hormone levels, Reproductive BioMedicine Online, Volume 39, Issue 1, 2019, Pages 141-148, ISSN 1472-6483,

Pregnancy and neonatal complications in women with polycystic ovary syndrome in relation to second-trimester anti-Müllerian hormone levels

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Author: Valdimarsdottir, Ragnheidur1; Valgeirsdottir, Heiddis1; Wikström, Anna-Karin1;
Organizations: 1Department of Women's and Children's Health, Uppsala University Uppsala, Sweden
2Centre for Clinical Research Sörmland, Uppsala University Eskilstuna, Sweden
3Department of Chemistry – BMC, Analytical Chemistry and Neurochemistry, Uppsala University Uppsala, Sweden
4Department of Obstetrics and Gynaecology, University of Oulu and Oulu University Hospital, Medical Research Center, PEDEGO Research Unit Oulu, Finland
5Laboratoire de Biochimie & Hormonologie, Centre de Biologie Pathologie, Centre Hospitalier Régional Universitaire, CHU de Lille, Lille, France
6Jean-Pierre Aubert Research Center (JPArc), Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, UMR-S 1172 Lille, France
7University of Lille, FHU 1,000 Days for Health, School of Medicine Lille, France
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
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Language: English
Published: Elsevier, 2019
Publish Date: 2020-02-27


Research question: An association has been found between high anti-Müllerian hormone (AMH) levels during pregnancy and the development of polycystic ovary syndrome (PCOS)-like phenotypic traits in mouse offspring. The aim of this study was to determine whether AMH levels are associated with maternal testosterone levels, and whether high AMH concentration influences the risk of developing PCOS-related adverse pregnancy outcomes.

Design: Maternal serum AMH, testosterone and sex hormone binding globulin levels were measured in blood samples taken in early second-trimester pregnancies from women with PCOS (n = 159) and healthy controls matched for body mass index (n = 320). Possible associations with preeclampsia, gestational hypertension, gestational diabetes, preterm birth and birthweight was explored by logistic and linear regression models.

Results: Women with PCOS had higher AMH, higher total testosterone levels and higher free androgen index than controls (P < 0.001 for all three parameters). Among women with PCOS, high testosterone levels (B = 2.7; β = 0.26; P = 0.001) and low first trimester body mass index (B = −0.5; β = −0.17; P = 0.043) remained independently associated with AMH. High AMH levels were associated with decreased risk of gestational hypertension (adjusted OR 0.55; 95% CI 0.34 to 0.87), but no association was found with other adverse pregnancy outcomes or birthweight.

Conclusions: Women with PCOS had higher AMH levels during pregnancy compared with controls, but high AMH was not associated with increased risk of adverse pregnancy outcomes or birthweight.

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Series: Reproductive biomedicine online
ISSN: 1472-6483
ISSN-E: 1472-6491
ISSN-L: 1472-6483
Volume: 39
Issue: 1
Pages: 141 - 148
DOI: 10.1016/j.rbmo.2019.02.004
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Copyright information: © 2019 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license