University of Oulu

Qing Liu, Xiaopeng Hong, Shuo Li, Zailiang Chen, Guoying Zhao, Beiji Zou, A spatial-aware joint optic disc and cup segmentation method, Neurocomputing, Volume 359, 2019, Pages 285-297, ISSN 0925-2312,

A spatial-aware joint optic disc and cup segmentation method

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Author: Liu, Qing1; Hong, Xiaopeng2,3; Li, Shuo4;
Organizations: 1School of Computer Science and Engineering, Central South University, China
2Xian Jiaotong University, China
3Centre for Machine Vision and Signal Analysis, University of Oulu, Finland
4Department of Medical Imaging, Western University, Canada
5Hunan Province Engineering Technology Research Center of Computer Vision and Intelligent Medical Treatment, China
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 2.1 MB)
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Language: English
Published: Elsevier, 2019
Publish Date: 2021-05-22


When dealing with the optic disc and cup in the optical nerve head images, their joint segmentation confronts two critical problems. One is that the spatial layout of the vessels in the optic nerve head images is variant. The other is that the landmarks for the optic cup boundaries are spatially sparse and at small spatial scale. To solve these two problems, we propose a spatial-aware joint segmentation method by explicitly considering the spatial locations of the pixels and learning the multi-scale spatially dense features. We formulate the joint segmentation task from a probabilistic perspective, and derive a spatial-aware maximum conditional probability framework and the corresponding error function. Accordingly, we provide an end-to-end solution by designing a spatial-aware neural network. It consists of three modules: the atrous CNN module to extract the spatially dense features, the pyramid filtering module to produce the spatial-aware multi-scale features, and the spatial-aware segmentation module to predict the labels of pixels. We validate the state-of-the-art performances of our spatial-aware segmentation method on two public datasets, i.e., ORIGA and DRISHTI. Based on the segmentation masks, we quantify the cup-to-disk values and apply them to the glaucoma screening. High correlation between the cup-to-disk values and the risks of the glaucoma is validated on the dataset ORIGA.

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Series: Neurocomputing
ISSN: 0925-2312
ISSN-E: 1872-8286
ISSN-L: 0925-2312
Volume: 359
Pages: 285 - 297
DOI: 10.1016/j.neucom.2019.05.039
Type of Publication: A1 Journal article – refereed
Field of Science: 113 Computer and information sciences
Funding: This work of Q. Liu is supported by the China Postdoctoral Science Foundation under Grant no. 2017M620356 and the Postdoctoral Science Foundation of Central South University; B. Zou and G. Zhao are partially supported by the International (Regional) Joint Research Program of Hunan Province under Grant no. 2017WK2074; B. Zou and Z. Chen are partially supported by the National Natural Science Foundation of China under Grant nos. 61573380 and 61672542.
Copyright information: © 2019 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license