University of Oulu

M. Peltokangas et al., "Lower Limb Pulse Rise Time as a Marker of Peripheral Arterial Disease," in IEEE Transactions on Biomedical Engineering, vol. 66, no. 9, pp. 2596-2603, Sept. 2019. doi: 10.1109/TBME.2019.2892407

Lower limb pulse rise time as a marker of peripheral arterial disease

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Author: Peltokangas, Mikko1; Vakhitov, Damir2; Suominen, Velipekka2;
Organizations: 1BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
2Division of Vascular Surgery, Department of Surgery, Tampere University Hospital
3Division of Interventional Radiology, Department of Radiology, Tampere University Hospital
4Infotech Oulu, Biomimetics and Intelligent Systems Group, University of Oulu
5BioMediTech, Faculty of Medicine and Health Technology, Tampere University
6Department of Surgery, Tampere University Hospital
7Oulu University Hospital
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link:
Language: English
Published: Institute of Electrical and Electronics Engineers, 2019
Publish Date: 2019-09-18


Objective: The aim of the study was to show if pulse rise times (PRTs) extracted from photoplethysmographic (PPG) pulse waves (PWs) have an association with peripheral arterial disease (PAD) or its endovascular treatment, percutanoeus transluminal angioplasty (PTA) of the superficial femoral artery.

Methods: Lower and upper limb PPG PWs were recorded and analyzed from 24 patients who suffered from PAD. The measurements were conducted before and after the treatment, and one month later by using transmission-mode PPG-probes placed in the index finger and second toe. Ankle-to-brachial pressure index and toe pressures were used as references in clinical patient measurements. PRTs, i.e., the time from the foot point to the peak point of the PW, were extracted from the PWs and compared bilaterally. The results from the PAD patients were also compared with 31 same-aged and 34 younger control subjects.

Results: Statistically significant differences were found between the pretreatment PRTs of the treated limb of the PAD patients and the same-aged control subjects (p < 10⁻⁹, Mann–Whitney U-test). The changes in the PRT of the treated lower limb were observed immediately after the PTA (p < 0.001, Student’s t -test), and after one month (p < 0.0005), whereas the PRTs of the non-treated lower limb and upper limb did not indicate changes between different examinations.

Conclusion: Results show that a PRT greater than 240 ms indicates PAD-lesions in the lower limb. Significance: This proof-of-concept study suggests that the PRT could be an effective and easy-to-use indicator for PAD and monitoring the effectiveness of its treatment.

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Series: IEEE transactions on bio-medical engineering
ISSN: 0018-9294
ISSN-E: 1558-2531
ISSN-L: 0018-9294
Volume: 66
Issue: 9
Pages: 2596 - 2603
DOI: 10.1109/TBME.2019.2892407
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
213 Electronic, automation and communications engineering, electronics
3121 General medicine, internal medicine and other clinical medicine
Funding: The work was funded by the Doctoral Programme of the President of Tampere University of Technology, Business Finland as a part of project VitalSens (decision ID 40103/14), Academy of Finland as part of project Vascular Biomechanics Assessment using printed soft electronics and advanced signa lprocessing (VBA) (decisions 310617 and 310618) and grants from Finnish Cultural Foundation/Pirkanmaa Regional Fund, Tekniikan edistämissäätiö and Emil Aaltonen Foundation.
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