|
|
Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults : results from a meta-analysis and exploratory meta-regression analysis |
|---|---|
| Author: | Veronese, Nicola1,2,3; Cereda, Emanuele4; Stubbs, Brendon5,6,7; |
| Organizations: |
1Department of Medicine (DIMED), Geriatrics Division, University of Padova, Italy 2Institute for Clinical Research and Education in Medicine (IREM), Padova, Italy 3National Research Council, Neuroscience Institute—Aging Branch, Padova, Italy
4Nutrition and Dietetics Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
5Physiotherapy Department, South London and Maudsley NHS FoundationTrust, Denmark Hill, London SE5 8AZ, United Kingdom 6Health Service and Population Research Department, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, United Kingdom 7Health, Social Care and Education, Anglia Ruskin University, Chelmsford, United Kingdom 8Department of Neurosciences, University of Padova, Padova, Italy 9National Health Care System, Monselice, Padova Local Unit ULSS 17, Italy 10Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy 11Surgical Pathology Unit, Santa Chiara Hospital, Trento, Italy 12South Oaks Hospital, Northwell Health,400 Sunsrise Highway, Amityville, NY 11701, USA 13Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA 14Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA 15Department of Clinical and Experimental Sciences, Brescia University, Brescia, Italy 16CEINGE Biotecnologie Avanzate, Napoli, Italy 17University of Helsinki and Helsinki University Hospital, Helsinki, Finland 18University of Oulu, Center for Life Course Health Research, Oulu, Finland 19Centre de Recherche Inserm, Bordeaux, France 20University Victor Segalen Bordeaux 2, Bordeaux, France 21CMRR Paris Nord AP-HP, Groupe Hospitalier Lariboisière Fernand-Widal Saint-Louis, INSERM, U942, Université Paris Diderot, Sorbonne Paris Cité, UMRS 942, Paris, France 22CESP, Univ. Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France 23University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France 24University of Zurich, Epidemiology, Biostatistics and Prevention Institute, Division of Chronic Disease Epidemiology, Hirschengraben 84, CH-8001 Zurich, Switzerland 25Division of Cardiology, Department of Science, Città della Salute e della Scienza, Turin, Italy 26Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy 27Department of Internal Medicine, Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil 28Department of Cardiology, Hospital Clínico Universitario, School of Medicine, University of Valencia, Valencia, (CIBER-CV), Spain 29Clinical Epidemiology and Biometric Unit, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy 30The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, New York, USA 31Hofstra Northwell School of Medicine, Hempstead, NY, USA 32The Feinstein Institute for Medical Research, Manhasset, NY, USA 33Albert Einstein College of Medicine, Bronx, NY, USA |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.8 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2019091928791 |
| Language: | English |
| Published: |
Elsevier,
2017
|
| Publish Date: | 2019-09-19 |
| Description: |
AbstractFrailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs) ±95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total of 31,343 participants were meta-analyzed. Using estimates from 10 cross-sectional cohorts, both frailty and pre-frailty were associated with higher odds of CVD than robust participants. Longitudinal data were obtained from 6 prospective cohort studies. After a median follow-up of 4.4 years, we identified an increased risk for faster onset of any-type CVD in the frail (HR = 1.70 [95%CI, 1.18–2.45]; I² = 66%) and pre-frail (HR = 1.23 [95%CI, 1.07–1.36]; I² = 67%) vs. robust groups. Similar results were apparent for time to CVD mortality in the frail and pre-frail groups. In conclusion, frailty and pre-frailty constitute addressable and independent risk factors for CVD in older adults. see all
|
| Series: |
Ageing research reviews |
| ISSN: | 1568-1637 |
| ISSN-E: | 1872-9649 |
| ISSN-L: | 1568-1637 |
| Volume: | 35 |
| Pages: | 63 - 73 |
| DOI: | 10.1016/j.arr.2017.01.003 |
| OADOI: | https://oadoi.org/10.1016/j.arr.2017.01.003 |
| Type of Publication: |
A2 Review article in a scientific journal |
| Field of Science: |
3142 Public health care science, environmental and occupational health |
| Subjects: | |
| Copyright information: |
© 2017 Elsevier B.V. Allr ights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. |
|
https://creativecommons.org/licenses/by-nc-nd/4.0/ |