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Franke, B., Stein, J. L., Ripke, S., Anttila, V., … Hibar, D. P. (2016). Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience, 19(3), 420–431. https://doi.org/10.1038/nn.4228

Genetic influences on schizophrenia and subcortical brain volumes : large-scale proof of concept

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Author: Franke, Barbara1,2,3; Stein, Jason L.4,5; Ripke, Stephan6,7,8;
Organizations: 1Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands
2Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands
3Donders Institute for Brain, Cognition and Behaviour, Raboud University, Nijmegen, the Netherlands
4Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA
5Neurogenetics Program, Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA
6Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
7Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
8Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany
9Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands
10Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
11Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
12FMRIB Centre, University of Oxford, Oxford, UK
13Department of Statistics & Warwick Manufacturing Group, University of Warwick, Coventry, UK
14Departments of Psychiatry & Human Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
15Division of Psychiatry, Royal Edinburgh Hospital, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
16Intramural Research Program, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA
17Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany
18Department of Biomedicine, Aarhus University, Aarhus, Denmark
19Center for integrated Sequencing, iSEQ, Aarhus University, Aarhus, Denmark
20NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
21Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
22Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen, Germany
23Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, New South Wales, Australia
24Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, New South Wales, Australia
25Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain
26Cibersam (Centro Investigación Biomédica en Red Salud Mental), Madrid, Spain
27Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA
28Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA
29Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
30Department of Child and Adolescent Psychiatry, Faculty of Medicine and University Hospital, Technische Universität Dresden, Dresden, Germany
31Georgia State University, Atlanta, Georgia, USA
32Mind Research Network, Albuquerque, New Mexico, USA
33QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
34School of Psychology, University of Queensland, Brisbane, Queensland, Australia
35MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK
36National Centre for Mental Health, Cardiff University, Cardiff, UK
37Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
38Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
39Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
40Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019091928793
Language: English
Published: Springer Nature, 2017
Publish Date: 2019-09-19
Description:

Abstract

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

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Series: Nature neuroscience
ISSN: 1097-6256
ISSN-E: 1546-1726
ISSN-L: 1097-6256
Volume: 19
Issue: 3
Pages: 420 - 431
DOI: 10.1038/nn.4228
OADOI: https://oadoi.org/10.1038/nn.4228
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
3112 Neurosciences
Subjects:
Copyright information: © 2019 Springer Nature Limited. This is a post-peer-review, pre-copyedit version of an article published in Nature Neuroscience. The final authenticated version is available online at: http://dx.doi.org/10.1038/nn.4228.