Marcovecchio, M. L., Tossavainen, P. H., Owen, K., Fullah, C., Benitez-Aguirre, P., Masi, S., … Dunger, D. B. (2017). Clustering of cardio-metabolic risk factors in parents of adolescents with type 1 diabetes and microalbuminuria. Pediatric Diabetes, 18(8), 947–954. https://doi.org/10.1111/pedi.12515
Clustering of cardio-metabolic risk factors in parents of adolescents with type 1 diabetes and microalbuminuria
|Author:||Marcovecchio, M. Loredana1; Tossavainen, Päivi H.2; Owen, Katharine3;|
1Department of Paediatrics, University of Cambridge, Cambridge, UK
2Department of Paediatrics, PEDEGO Research Unit and Medical Research Centre Oulu, Oulu, University Hospital and University of Oulu, Oulu, Finland
3Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK
4Institute of Endocrinology and Diabetes, University of Sydney, Sydney, Australia
5Vascular Physiology Unit, Institute of Cardiovascular Science, University College London, London, UK
6MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
7WellChild Laboratory, King’s College London, Evelina Children’s Hospital, London, UK
|Online Access:||PDF Full Text (PDF, 0.3 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019091928796
John Wiley & Sons,
|Publish Date:|| 2019-09-19
Objective: To evaluate the association between a clustering of cardio‐metabolic risk factors in parents and the development of microalbuminuria (MA) in their offspring with childhood‐onset type 1 diabetes (T1D).
Methods: The study population comprised 53 parents (mean age [±SD]: 56.7±6.2 years) of 35 T1D young people with MA (MA+) and 86 parents (age: 56.1±6.3 years) of 50 matched offspring with normoalbuminuria (MA–), who underwent clinical, biochemical and cardiovascular imaging assessments. The primary study endpoint was the difference between parents from the MA+ and MA− groups in a cardio‐metabolic risk score, calculated as the average value of the standardized measures (z‐scores) for waist circumference, blood pressure, fasting glucose, insulin, HDL‐cholesterol and triglycerides levels. Cardiovascular parameters, including carotid intima‐media thickness (cIMT), flow‐mediated dilatation (FMD) and pulse wave velocity (PWV), were also assessed. A DXA scan was performed to assess body composition.
Results: The cardio‐metabolic risk score was significantly higher in parents of MA+ compared to parents of MA− offspring (mean [95% CI]: 1.066[0.076; 2.056] vs −0.268[−0.997; 0.460], P = .03). Parents of MA+ offspring had slightly higher values of waist circumference, lipids, insulin and blood pressure, although only diastolic blood pressure was statistically different between the 2 groups (P = .0085). FMD, cIMT, PWV (all P > .3), and DXA parameters (all P > .2) were not significantly different between the 2 groups.
Conclusions: Parents of young offspring with childhood‐onset T1D and MA showed an abnormal metabolic profile, reflected by a calculated risk score. The finding supports the role of a familial predisposition to risk of developing diabetic nephropathy.
|Pages:||947 - 954|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
The study was supported by a grant from Diabetes UK (09/0003859). P.H.T. was financially supported by Academy of Finland (decision 130171); The Diabetes Research Foundation, Finland; Foundation for Pediatric Research, Finland; The Alma and K. A. Snellman Foundation, Oulu, Finland; and The Finnish Medical Foundation.
|Academy of Finland Grant Number:||
130171 (Academy of Finland Funding decision)
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Marcovecchio, M. L., Tossavainen, P. H., Owen, K., Fullah, C., Benitez-Aguirre, P., Masi, S., … Dunger, D. B. (2017). Clustering of cardio-metabolic risk factors in parents of adolescents with type 1 diabetes and microalbuminuria. Pediatric Diabetes, 18(8), 947–954. https://doi.org/10.1111/pedi.12515, which has been published in final form at https://doi.org/10.1111/pedi.12515. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.