Daily physical activity and lung function decline in adult-onset asthma : a 12-year follow-up study
Loponen, Juho; Ilmarinen, Pinja; Tuomisto, Leena E.; Niemelä, Onni; Tommola, Minna; Nieminen, Pentti; Lehtimäki, Lauri; Kankaanranta, Hannu (2018-10-24)
Juho Loponen, Pinja Ilmarinen, Leena E. Tuomisto, Onni Niemelä, Minna Tommola, Pentti Nieminen, Lauri Lehtimäki & Hannu Kankaanranta (2018) Daily physical activity and lung function decline in adult-onset asthma: a 12-year follow-up study, European Clinical Respiratory Journal, 5:1, DOI: 10.1080/20018525.2018.1533753
© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by-nc/4.0/
https://urn.fi/URN:NBN:fi-fe2019100230809
Tiivistelmä
Abstract
Background: There is a lack of knowledge on the association between daily physical activity and lung function in patients with asthma.
Objective: This study aims to examine the association between daily physical activity and asthma control, lung function, and lung function decline in patients with adult-onset asthma.
Design: This study is part of Seinäjoki Adult Asthma Study (SAAS), where 201 patients were followed for 12 years after asthma diagnosis. Daily physical activity was assessed at follow-up by a structured questionnaire and used to classify the population into subgroups of low (≤240 min) or high (>240 min) physical activity. Three spirometry evaluation points were used: 1. diagnosis, 2. the maximum lung function during the first 2.5 years after diagnosis (Max0–2.5), 3. follow-up at 12 years.
Results: High physical activity group had slower annual FEV1 (p<0.001) and FVC (p<0.018) decline. Additionally, the high physical activity group had higher FEV₁ values at follow-up, and higher FEV₁/FVC ratios at follow-up and diagnosis. There was no difference in BMI, smoking, medication, or frequency of physical exercise between high and low physical activity groups. Differences remained significant after adjustments for possible confounding factors.
Conclusion: This is the first demonstration of an association between long-term FEV₁ decline and daily physical activity in clinical asthma. Low physical activity is independently associated with faster decline in lung function. Daily physical activity should be recommended in treatment guidelines in asthma.
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