University of Oulu

Tiainen, S., Kiviniemi, A., Hautala, A., Huikuri, H., Ukkola, O., Tokola, K., … Vasankari, T. (2018). Effects of a Two-Year Home-Based Exercise Training Program on Oxidized LDL and HDL Lipids in Coronary Artery Disease Patients with and without Type-2 Diabetes. Antioxidants, 7(10), 144.

Effects of a two-year home-based exercise training program on oxidized LDL and HDL lipids in coronary artery disease patients with and without type-2 diabetes

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Author: Tiainen, Sanna1,2; Kiviniemi, Antti3; Hautala, Arto4;
Organizations: 1Sports Institute of Finland, 19100 Vierumäki, Finland
2Department of Health and Exercise and Paavo Nurmi Center, University of Turku, 20540 Turku, Finland
3Research of Internal Medicine, Medical Research Center Oulu, Oulu University, Hospital and University of Oulu, 90220 Oulu, Finland
4 Cardiovascular Research Group, Division of Cardiology, Oulu University Hospital, University of Oulu, 90220 Oulu, Finland
5The UKK Institute for Health Promotion Research, 33500 Tampere, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.3 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2018
Publish Date: 2019-10-02


We investigated the effect of two-year home-based exercise training program on oxidized low-density lipoprotein LDL (ox-LDL) and high-density lipoprotein HDL (ox-HDL) lipids in patients with coronary artery disease (CAD), both with and without type-2 diabetes (T2D). Analysis of lipoprotein-oxidized lipids was based on the determination of baseline conjugated dienes in lipoprotein lipids. In order to study the effect of an exercise load on ox-LDL and ox-HDL lipids patients in both CAD and CAD + T2D intervention, groups were divided in three based on exercise load (high, medium, and low). During the two-year home-based exercise training program, the study showed that only higher training volume resulted in a decreased concentration of ox-LDL, while the two groups with lower training volumes showed no change. This result indicates that the training load needs to be sufficiently high in order to decrease the concentration of atherogenic ox-LDL lipids in patients with CAD and CAD + T2D. Interestingly, the concentration of ox-HDL did not change in any of the subgroups. This could indicate that the lipid peroxide-transporting capacity of HDL, suggested by results from exercise training studies in healthy adults, may not function similarly in CAD patients with or without T2D. Moreover, the lipid-lowering medication used may have had an influence on these results.

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Series: Antioxidants
ISSN: 2076-3921
ISSN-E: 2076-3921
ISSN-L: 2076-3921
Volume: 7
Issue: 10
Article number: 144
DOI: 10.3390/antiox7100144
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: This research was funded by the Finnish Technology Development Center (TEKES), Helsinki, Finland; the Academy of Finland (#267435), Helsinki, Finland; the Sigrid Juselius Foundation, Helsinki, Finland; the Paulo Foundation, Espoo, Finland; and the Finnish Foundation for Cardiovascular Research, Helsinki, Finland.
Copyright information: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (