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Plasma heme scavengers alpha-l-microglobulin and hemopexin as biomarkers in high-risk pregnancies |
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| Author: | Kalapotharakos, Grigorios1,2; Murtoniemi, Katja3,4; Åkerström, Bo5; |
| Organizations: |
1Department of Clinical Sciences Lund, Skåne University Hospital, Lund, Sweden 2Department of Obstetrics and Gynecology, Lund University, Lund, Sweden 3Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
4Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, Turku, Finland
5Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden 6HUSLAB, Helsinki University Hospital, Helsinki, Finland 7Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland 8National Institute for Health and Welfare, Helsinki, Finland 9Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 10Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland 11Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland 12Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 13Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland 14Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland 15Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.7 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2019100230813 |
| Language: | English |
| Published: |
Frontiers Media,
2019
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| Publish Date: | 2019-10-02 |
| Description: |
AbstractWomen with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress. see all
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| Series: |
Frontiers in physiology |
| ISSN: | 1664-042X |
| ISSN-E: | 1664-042X |
| ISSN-L: | 1664-042X |
| Volume: | 10 |
| Article number: | 300 |
| DOI: | 10.3389/fphys.2019.00300 |
| OADOI: | https://oadoi.org/10.3389/fphys.2019.00300 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics |
| Subjects: | |
| Funding: |
This project has been partly supported by Erasmus + Program of the European Union (Framework agreement number: 2013-0040). The PREDO project has been supported by EVO research funding (A special Finnish state subsidy for health science research), Academy of Finland, Signe and Ane Gyllenberg Foundation, Sigrid Juselius Foundation, University of Helsinki Research Funds, Finnish Medical Foundation, Juho Vainio Foundation, Novo Nordisk Foundation, Jane and Aatos Erkko Foundation, and Päivikki and Sakari Sohlberg Foundation. |
| Copyright information: |
© 2019 Kalapotharakos, Murtoniemi, Åkerström, Hämäläinen, Kajantie, Räikkönen, Villa, Laivuori and Hansson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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https://creativecommons.org/licenses/by/4.0/ |