University of Oulu

Kalapotharakos, G., Murtoniemi, K., Åkerström, B., Hämäläinen, E., Kajantie, E., Räikkönen, K., … Hansson, S. R. (2019). Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies. Frontiers in Physiology, 10.

Plasma heme scavengers alpha-l-microglobulin and hemopexin as biomarkers in high-risk pregnancies

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Author: Kalapotharakos, Grigorios1,2; Murtoniemi, Katja3,4; Åkerström, Bo5;
Organizations: 1Department of Clinical Sciences Lund, Skåne University Hospital, Lund, Sweden
2Department of Obstetrics and Gynecology, Lund University, Lund, Sweden
3Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
4Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, Turku, Finland
5Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
6HUSLAB, Helsinki University Hospital, Helsinki, Finland
7Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland
8National Institute for Health and Welfare, Helsinki, Finland
9Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
10Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
11Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
12Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
13Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
14Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland
15Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
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Language: English
Published: Frontiers Media, 2019
Publish Date: 2019-10-02


Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.

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Series: Frontiers in physiology
ISSN: 1664-042X
ISSN-E: 1664-042X
ISSN-L: 1664-042X
Volume: 10
Article number: 300
DOI: 10.3389/fphys.2019.00300
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Funding: This project has been partly supported by Erasmus + Program of the European Union (Framework agreement number: 2013-0040). The PREDO project has been supported by EVO research funding (A special Finnish state subsidy for health science research), Academy of Finland, Signe and Ane Gyllenberg Foundation, Sigrid Juselius Foundation, University of Helsinki Research Funds, Finnish Medical Foundation, Juho Vainio Foundation, Novo Nordisk Foundation, Jane and Aatos Erkko Foundation, and Päivikki and Sakari Sohlberg Foundation.
Copyright information: © 2019 Kalapotharakos, Murtoniemi, Åkerström, Hämäläinen, Kajantie, Räikkönen, Villa, Laivuori and Hansson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.