Role of prolyl hydroxylation in the molecular interactions of collagens
Rappu, Pekka; Salo, Antti M.; Myllyharju, Johanna; Heino, Jyrki (2019-07-26)
Rappu, P., Salo, A., Myllyharju, J., Heino, J. (2019) Role of prolyl hydroxylation in the molecular interactions of collagens, 63 (3), 325-335. doi:10.1042/EBC20180053
© 2019 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).
https://creativecommons.org/licenses/by-nc-nd/4.0/
https://urn.fi/URN:NBN:fi-fe2019100731553
Tiivistelmä
Abstract
Co- and post-translational hydroxylation of proline residues is critical for the stability of the triple helical collagen structure. In this review, we summarise the biology of collagen prolyl 4-hydroxylases and collagen prolyl 3-hydroxylases, the enzymes responsible for proline hydroxylation. Furthermore, we describe the potential roles of hydroxyproline residues in the complex interplay between collagens and other proteins, especially integrin and discoidin domain receptor type cell adhesion receptors. Qualitative and quantitative regulation of collagen hydroxylation may have remarkable effects on the properties of the extracellular matrix and consequently on the cell behaviour.
Kokoelmat
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