University of Oulu

Koivuaho, E., Laru, J., Ojaniemi, M., Puukka, K., Kettunen, J., Tapanainen, J. S., … Piltonen, T. T. (2019). Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood—longitudinal analysis of BMI data from birth to age 46 in cases of PCOS. International Journal of Obesity, 43(7), 1370–1379. https://doi.org/10.1038/s41366-019-0318-z

Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS

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Author: Koivuaho, E.1; Laru, J.1; Ojaniemi, M.2;
Organizations: 1Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
2Department of Children and Adolescents, PEDEGO Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
3NordLab Oulu, Department of Clinical Chemistry, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
4Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland
5Biocenter Oulu, University of Oulu, Oulu, Finland
6Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
7Institute of Reproductive and Developmental Biology, Department of Surgery & Cancer, Imperial College London, London, UK
8Center for Life Course Health Research, University of Oulu, Oulu, Finland
9Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
10Unit of Primary Care, Oulu University Hospital, Oulu, Finland
11Department of Genomic of Complex Diseases, School of Public Health, Imperial College London, London, UK
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019101032117
Language: English
Published: Springer Nature, 2019
Publish Date: 2019-10-10
Description:

Abstract

Background: Adiposity rebound (AR), the second BMI rise in childhood at around the age of 6 years, is associated with obesity and metabolic alteration in later life. Given that polycystic ovary syndrome (PCOS) has a strong metabolic component, early life growth patterns could reveal a risk of PCOS. Thus, we aimed to investigate the associations between age at AR and PCOS diagnosis and BMI later in life.

Materials and methods: This study is part of a prospective, population-based longitudinal study, where women with PCOS diagnosis by age 46 (n = 280) were compared with asymptomatic women (CTRLs, n = 1573). Weight and height data from birth to age 13 years, at age at menarche, and at ages 31 and 46 years were analyzed.

Results: Women with PCOS had lower birth weight (3357 ± 477 vs. 3 445 ± 505 g, p < 0.001), earlier age at AR (5.2 ± 1.0 vs. 5.6 ± 0.90 years, p < 0.001) and higher BMI from AR onwards compared with controls. Early timing of AR was associated with PCOS diagnosis independently of BMI (OR 1.62, 95% Cl 1.37–1.92). Women with PCOS and early AR had higher BMI at 31 and 46 years when compared to controls with early AR. The age at AR did not associate with T levels at ages 31 or 46 years.

Conclusions: Early AR was associated with PCOS diagnosis and high BMI in adulthood. Adolescent girls with early AR and persisting obesity should be screened for PCOS symptoms, such as persistent irregular cycles and hirsutism.

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Series: International journal of obesity
ISSN: 0307-0565
ISSN-E: 1476-5497
ISSN-L: 0307-0565
Volume: 43
Issue: 7
Pages: 1370 - 1379
DOI: 10.1038/s41366-019-0318-z
OADOI: https://oadoi.org/10.1038/s41366-019-0318-z
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Subjects:
Funding: The Sigrid Jusélius Foundation, The Finnish Medical Association, The Academy of Finland, and Novo Nordisk Foundation.
Copyright information: © The Authors 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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