University of Oulu

Zherebtsova AI, Dremin VV,Makovik IN, Zherebtsov EA,Dunaev AV, Goltsov A, Sokolovski SGand Rafailov EU (2019) MultimodalOptical Diagnostics of theMicrohaemodynamics in Upperand Lower Limbs. Front. Physiol. 10:416. doi: 10.3389/fphys.2019.00416

Multimodal optical diagnostics of the microhaemodynamics in upper and lower limbs

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Author: Zherebtsova, Angelina I.1; Dremin, Viktor V.1; Makovik, Irina N.1;
Organizations: 1Research and Development Center of Biomedical Photonics, Orel State University, Oryol, Russia
2Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
3Optoelectronics and Biomedical Photonics Group, Aston Institute of Photonic Technologies, School of Engineering and Applied Science, Aston University, Birmingham, United Kingdom
4School of Applied Sciences, Abertay University, Dundee, United Kingdom
5International Center of Critical Technologies in Medicine, Saratov State University, Saratov, Russia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.8 MB)
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Language: English
Published: Frontiers Media, 2019
Publish Date: 2019-10-10


The introduction of optical non-invasive diagnostic methods into clinical practice can substantially advance in the detection of early microcirculatory disorders in patients with different diseases. This paper is devoted to the development and application of the optical non-invasive diagnostic approach for the detection and evaluation of the severity of microcirculatory and metabolic disorders in rheumatic diseases and diabetes mellitus. The proposed methods include the joint use of laser Doppler flowmetry, absorption spectroscopy and fluorescence spectroscopy in combination with functional tests. This technique showed the high diagnostic importance for the detection of disturbances in peripheral microhaemodynamics. These methods have been successfully tested as additional diagnostic techniques in the field of rheumatology and endocrinology. The sensitivity and specificity of the proposed diagnostic procedures have been evaluated.

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Series: Frontiers in physiology
ISSN: 1664-042X
ISSN-E: 1664-042X
ISSN-L: 1664-042X
Volume: 10
Article number: 416
DOI: 10.3389/fphys.2019.00416
Type of Publication: A1 Journal article – refereed
Field of Science: 1184 Genetics, developmental biology, physiology
3111 Biomedicine
Funding: SS and ER were partially supported by Russian Science Foundation (Grant No. 18-15-00172). EZ kindly acknowledges for personal support from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement No. 703145 and Academy of Finland, grant No. 318281. AZ (regarding the experimental studies of the blood perfusion and skin temperature dynamics for functional diagnostics of intradermal finger vessels) was funded by the Russian Science Foundation (Grant No. 18-79-00237).
Academy of Finland Grant Number: 318281
Detailed Information: 318281 (Academy of Finland Funding decision)
Copyright information: © 2019 Zherebtsova, Dremin, Makovik, Zherebtsov, Dunaev, Goltsov, Sokolovski and Rafailov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.