University of Oulu

Johannes Lieslehto, Vesa J Kiviniemi, Tanja Nordström, Jennifer H Barnett, Graham K Murray, Peter B Jones, Tomáš Paus, Juha Veijola, Polygenic Risk Score for Schizophrenia and Face-Processing Network in Young Adulthood, Schizophrenia Bulletin, Volume 45, Issue 4, July 2019, Pages 835–845, https://doi.org/10.1093/schbul/sby139

Polygenic risk score for schizophrenia and face-processing network in young adulthood

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Author: Lieslehto, Johannes1,2; Kiviniemi, Vesa J.2,3; Nordström, Tanja2,4;
Organizations: 1Department of Psychiatry, Research Unit of Clinical Neuroscience, Faculty of Medicine, University of Oulu, Oulu, Finland
2Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
3Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
4Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
5Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, UK
6Cambridge Cognition Ltd, Cambridge, UK
7Child Mind Institute, New York, NY
8Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada
9Department of Psychology, University of Toronto, Toronto, Ontario, Canada
10Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
11Department of Psychiatry, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019101132260
Language: English
Published: Oxford University Press, 2019
Publish Date: 2019-10-11
Description:

Abstract

Development of schizophrenia relates to both genetic and environmental factors. Functional deficits in many cognitive domains, including the ability to communicate in social interactions and impaired recognition of facial expressions, are common for patients with schizophrenia and might also be present in individuals at risk of developing schizophrenia. Here we explore whether an individual’s polygenic risk score (PRS) for schizophrenia is associated with the degree of interregional similarities in blood oxygen level–dependent (BOLD) signal and gray matter volume of the face-processing network and whether the exposure to early adversity moderates this association. A total of 90 individuals (mean age 22 years, both functional and structural data available) were used for discovery analyses, and 211 individuals (mean age 26 years, structural data available) were used for replication of the structural findings. Both samples were drawn from the Northern Finland Birth Cohort 1986. We found that the degree of interregional similarities in BOLD signal and gray matter volume vary as a function of PRS; lowest interregional correlation (both measures) was observed in individuals with high PRS. We also replicated the gray matter volume finding. We did not find evidence for an interaction between early adversity and PRS on the interregional correlation of BOLD signal and gray matter volume. We speculate that the observed group differences in PRS-related correlations in both modalities may result from differences in the concurrent functional engagement of the face-processing regions over time, eg, via differences in exposure to social interaction with other people.

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Series: Schizophrenia bulletin
ISSN: 0586-7614
ISSN-E: 1745-1707
ISSN-L: 0586-7614
Volume: 45
Issue: 4
Pages: 835 - 845
DOI: 10.1093/schbul/sby139
OADOI: https://oadoi.org/10.1093/schbul/sby139
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Subjects:
Funding: Finnish Medical Association (to JL); Yrjö Jahnsson’s Foundation (to JL); Psykiatrian tutkimussäätiö (Finnish Foundation for Psychiatric Research) (to JL); Jalmari and Rauha Ahokas Foundation (to JL); Academy of Finland (124257, 212818, 214273 to JV); Sigrid Juselius Foundation (to JV); Signe and Ane Gyllenberg Foundation, Finland (to JV); Alfred Kordelin Foundation (to JL); Orion Foundation (to JL).
Academy of Finland Grant Number: 124257
212818
214273
Detailed Information: 124257 (Academy of Finland Funding decision)
212818 (Academy of Finland Funding decision)
214273 (Academy of Finland Funding decision)
Copyright information: © The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
  https://creativecommons.org/licenses/by-nc/4.0/