Wail Nammas, Tuomas Kiviniemi, Axel Schlitt, Andrea Rubboli, Josè Valencia, Gregory Y.H. Lip, Pasi P. Karjalainen, Fausto Biancari, K.E. Juhani Airaksinen, Value of DAPT score to predict adverse outcome in patients with atrial fibrillation undergoing percutaneous coronary intervention: A post-hoc analysis from the AFCAS registry, International Journal of Cardiology, Volume 253, 2018, Pages 35-39, ISSN 0167-5273, https://doi.org/10.1016/j.ijcard.2017.07.074
Value of DAPT score to predict adverse outcome in patients with atrial fibrillation undergoing percutaneous coronary intervention : a post-hoc analysis from the AFCAS registry
|Author:||Nammas, Wail1; Kiviniemi, Tuomas2; Schlitt, Axel3;|
1Heart Center, Satakunta Central Hospital, Pori, Finland
2Heart Center, Turku University Hospital, University of Turku, Turku, Finland
3Medical Faculty, Martin Luther-University Halle, Germany, Department of Cardiology, Paracelsus Harz-Clinic Bad Suderode, Germany
4Division of Cardiology, Laboratory of Interventional Cardiology, Ospedale Maggiore, Bologna, Italy
5Department of Cardiology, General Hospital University of Alicante, Spain
6University of Birmingham Institute of Cardiovascular Sciences, City Hospital, UK, and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
7Department of Surgery, Oulu University Hospital, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 0.2 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019102134030
|Publish Date:|| 2019-10-21
Background: The DAPT score identifies patients with expected benefit from extended dual antiplatelet therapy beyond 1 year after percutaneous coronary intervention (PCI). In a post-hoc analysis from the AFCAS registry, we explored the value of DAPT score to predict outcome in patients with atrial fibrillation (AF) undergoing PCI.
Methods and results: Outcome measures included major adverse cardiac/cerebrovascular events (MACCE) [all-cause death, myocardial infarction, repeat revascularization, stent thrombosis, or stroke/transient ischemic attack] and bleeding events. At 12-month follow-up, patients with a DAPT score ≥ 1 had a higher incidence of MACCE, all-cause death, myocardial infarction (p = 0.004, p = 0.006, and p = 0.013, respectively), but a similar bleeding rate (p = 0.66), versus those with a DAPT score < 1. In a subgroup of patients at high risk of stroke who received triple therapy for 1 month only, DAPT score ≥ 1 was associated with a higher incidence of MACCE, all-cause death, myocardial infarction (p = 0.002, p = 0.015, and p = 0.039, respectively), but a similar bleeding rate (p = 0.81).
Conclusions: In AF patients undergoing PCI, a DAPT score ≥ 1 was associated with a higher incidence of thrombotic events, and a similar incidence of bleeding events, compared with a DAPT score < 1. These results were consistent in patients at high risk of stroke who received triple therapy for 1 month.
International journal of cardiology
|Pages:||35 - 39|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
© 2017 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.