Chi, T., Horbach, T., Götz, C., Kietzmann, T., & Dimova, E. (2019). Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis. Cancers, 11(4), 523. https://doi.org/10.3390/cancers11040523
Cyclin-dependent kinase 5 (CDK5)-mediated phosphorylation of upstream stimulatory factor 2 (USF2) contributes to carcinogenesis
|Author:||Chi, Tabughang Franklin1; Horbach, Tina1; Götz, Claudia2;|
1Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, Finland
2Medical Biochemistry and Molecular Biology, Saarland University, 66421 Homburg, Germany
|Online Access:||PDF Full Text (PDF, 1.3 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019102134063
Multidisciplinary Digital Publishing Institute,
|Publish Date:|| 2019-10-21
The transcription factor USF2 is supposed to have an important role in tumor development. However, the regulatory mechanisms contributing to the function of USF2 are largely unknown. Cyclin-dependent kinase 5 (CDK5) seems to be of importance since high levels of CDK5 were found in different cancers associated with high USF2 expression. Here, we identified USF2 as a phosphorylation target of CDK5. USF2 is phosphorylated by CDK5 at two serine residues, serine 155 and serine 222. Further, phosphorylation of USF2 at these residues was shown to stabilize the protein and to regulate cellular growth and migration. Altogether, these results delineate the importance of the CDK5-USF2 interplay in cancer cells.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
1182 Biochemistry, cell and molecular biology
This research was funded by the Academy of Finland SA296027, the Jane and Aatos Erkko Foundation, the Finnish Cancer Foundation, the University of Oulu, and Biocenter Oulu (to T.K.).
|Academy of Finland Grant Number:||
296027 (Academy of Finland Funding decision)
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).