University of Oulu

Kubaichuk, K., & Kietzmann, T. (2019). Involvement of E3 Ligases and Deubiquitinases in the Control of HIF-α Subunit Abundance. Cells, 8(6), 598.

Involvement of E3 ligases and deubiquitinases in the control of HIF-α subunit abundance

Saved in:
Author: Kubaichuk, Kateryna1; Kietzmann, Thomas1
Organizations: 1Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.4 MB)
Persistent link:
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2019
Publish Date: 2019-10-21


The ubiquitin and hypoxia-inducible factor (HIF) pathways are cellular processes involved in the regulation of a variety of cellular functions. Enzymes called ubiquitin E3 ligases perform protein ubiquitylation. The action of these enzymes can be counteracted by another group of enzymes called deubiquitinases (DUBs), which remove ubiquitin from target proteins. The balanced action of these enzymes allows cells to adapt their protein content to a variety of cellular and environmental stress factors, including hypoxia. While hypoxia appears to be a powerful regulator of the ubiquitylation process, much less is known about the impact of DUBs on the HIF system and hypoxia-regulated DUBs. Moreover, hypoxia and DUBs play crucial roles in many diseases, such as cancer. Hence, DUBs are considered to be promising targets for cancer cell-specific treatment. Here, we review the current knowledge about the role DUBs play in the control of HIFs, the regulation of DUBs by hypoxia, and their implication in cancer progression.

see all

Series: Cells
ISSN: 2073-4409
ISSN-E: 2073-4409
ISSN-L: 2073-4409
Volume: 8
Issue: 6
Article number: 598
DOI: 10.3390/cells8060598
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3111 Biomedicine
1182 Biochemistry, cell and molecular biology
Funding: This work was supported by grants from the Academy of Finland (SA296027), the Jane and Aatos Erkko Foundation, the Finnish Cancer Foundation, the Sigrid Juselius Foundation, Biocenter Oulu, and the European Cooperation in Science and Technology Organization (COST Action BM1203/EU-ROS).
Academy of Finland Grant Number: 296027
Detailed Information: 296027 (Academy of Finland Funding decision)
Copyright information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (