Liver zonation in health and disease : hypoxia and hypoxia-inducible transcription factors as concert masters |
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Author: | Kietzmann, Thomas1 |
Organizations: |
1Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, Finland |
Format: | article |
Version: | published version |
Access: | open |
Online Access: | PDF Full Text (PDF, 1 MB) |
Persistent link: | http://urn.fi/urn:nbn:fi-fe2019102134097 |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute,
2019
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Publish Date: | 2019-10-21 |
Description: |
AbstractThe liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as β-catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradient, appear to be contributors. Interestingly, hypoxia and hypoxia-inducible transcription factors can orchestrate those pathways. In the current review, we connect novel findings of liver zonation in health and disease and provide a view about the dynamic interplay between these different pathways and cell-types to drive liver zonation and systemic homeostasis. see all
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Series: |
International journal of molecular sciences |
ISSN: | 1661-6596 |
ISSN-E: | 1422-0067 |
ISSN-L: | 1661-6596 |
Volume: | 20 |
Issue: | 9 |
Article number: | 2347 |
DOI: | 10.3390/ijms20092347 |
OADOI: | https://oadoi.org/10.3390/ijms20092347 |
Type of Publication: |
A2 Review article in a scientific journal |
Field of Science: |
1182 Biochemistry, cell and molecular biology |
Subjects: | |
Funding: |
The work was supported by grants from the Academy of Finland (SA 296027), Jane and Aatos Erkko Foundation, Finnish Cancer Foundation, Sigrid Juselius Foundation, Biocenter Oulu, and the European Cooperation in Science and Technology Organization (COST Action BM1203/EU-ROS). |
Academy of Finland Grant Number: |
296027 |
Detailed Information: |
296027 (Academy of Finland Funding decision) |
Copyright information: |
© 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) |
https://creativecommons.org/licenses/by/4.0/ |