Sedative load and salivary secretion and xerostomia in community-dwelling older people
|Author:||Tiisanoja, Antti1; Syrjälä, Anna-Maija1,2; Komulainen, Kaija3,4;|
1Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland
2Dental Training Clinic, Social and Health services, City of Oulu, Finland
3School of Pharmacy, University of Eastern Finland, Kuopio, Finland
4Social and Health Centre of Kuopio, Kuopio, Finland
5Department of Social Pharmacy, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
6Unit of Clinical Pharmacology and Geriatric Pharmacotherapy, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
7Institute of Dentistry, University of Eastern Finland, Kuopio, Finland
8Oral and Maxillofacial Department, Oulu University Hospital, Oulu, Finland
9Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Kuopio, Finland
|Online Access:||PDF Full Text (PDF, 0.4 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019102334310
John Wiley & Sons,
|Publish Date:|| 2019-10-23
Objective: The aim was to investigate how sedative load and the total number of drugs used are related to hyposalivation and xerostomia among 75‐year‐old or older dentate, non‐smoking, community‐dwelling people.
Materials and Methods: The study population consisted of 152 older people from the Oral Health GeMS study. The data were collected by interviews and clinical examinations during 2004–2005. Sedative load, which measures the cumulative effect of taking multiple drugs with sedative properties, was calculated using the Sedative Load Model.
Results: The results showed that participants with a sedative load of either 1–2 or ≥3 had an increased likelihood of having low stimulated salivary flow (<0.7 ml/min; OR: 2.4; CI: 0.6–8.6 and OR: 11; CI: 2.2–59; respectively) and low unstimulated salivary flow (<0.1 ml/min; OR: 2.7, CI: 1.0–7.4 and OR: 4.5, CI: 1.0–20, respectively) compared with participants without a sedative load. Participants with a sedative load ≥3 had an increased likelihood of having xerostomia (OR: 2.5, CI: 0.5–12) compared with participants without a sedative load. The results showed that the association between the total number of drugs and hyposalivation was weaker than the association between sedative load and hyposalivation.
Conclusion: Sedative load is strongly related to hyposalivation and to a lesser extent with xerostomia. The adverse effects of drugs on saliva secretion are specifically related to drugs with sedative properties.
|Pages:||177 - 184|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
The GeMS study has been supported by the Social Insurance Institute and the City of Kuopio. A personal grant was given to Antti Tiisanoja by the August & Lyydia Heino Foundation. We thank Paula Pesonen for her statistical guidance.
© 2014 John Wiley & Sons A/S and The Gerodontology Association. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: doi: 10.1111/ger.12129 Sedative load and salivary secretion and xerostomia in community‐dwelling older people , which has been published in final form at https://doi.org/10.1111/ger.12129. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.