Tiisanoja, A, Syrjälä, A‐M, Tertsonen, M, et al. Oral diseases and inflammatory burden and Alzheimer's disease among subjects aged 75 years or older. Spec Care Dentist. 2019; 39: 158– 165. https://doi.org/10.1111/scd.12357
Oral diseases and inflammatory burden and Alzheimer’s disease among subjects aged 75 years or older
|Author:||Tiisanoja, Antti1; Syrjälä, Anna-Maija1,2,3; Tertsonen, Miia1;|
1Unit of Oral Health Sciences Research, University of Oulu, Oulu, Finland
2Dental Training Clinic, Social and Health Services, Oulu, Finland
3Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
4Institute of Dentistry, University of Eastern Finland, Kuopio, Finland
5Faculty of Medicine, University of Oulu, Oulu, Finland
6School of Pharmacy, University of Eastern Finland, Kuopio, Finland
7Research Center of Geriatric Care, University of Eastern Finland, Kuopio, Finland
|Online Access:||PDF Full Text (PDF, 0.2 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019102334322
John Wiley & Sons,
|Publish Date:|| 2020-01-29
Aim: To study whether dental caries, periodontal disease, and stomatitis, and the related inflammatory burden associate with diagnosed Alzheimer’s disease (AD) and dementia among older people.
Methods: The study population included 170 individuals aged ≥75 years. The primary outcome was diagnosed AD and the secondary outcome was any types of diagnosed dementia. Information about participants’ oral diseases and the related inflammatory burden was based on the clinical oral examination. Relative risks (RRs) and confidence intervals (CIs) were estimated using regression models.
Results: Dental caries, the presence of ≥3 carious teeth (RR: 3.47, 95% CI: 1.09–11.1) and the number of carious teeth (RR: 1.24, CI: 1.11–1.39), and inflammatory burden (RR: 1.44, CI: 1.04–2.01) were associated with a higher likelihood of having AD. Also, periodontal disease and stomatitis were associated, although nonstatistically, with AD and dementia. The risk estimates for any type of dementia were in most cases lower than for AD.
Conclusion: Oral diseases and the related inflammatory burden were in most cases associated more strongly with diagnosed AD than dementia in general. Of the oral diseases studied, the strongest association was between dental caries and AD.
Special care in dentistry
|Pages:||158 - 165|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
The original GeMS study was supported by the Social Insurance Institute and the City of Kuopio.
© 2019 Special Care Dentistry Association and Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Tiisanoja, A, Syrjälä, A‐M, Tertsonen, M, et al. Oral diseases and inflammatory burden and Alzheimer's disease among subjects aged 75 years or older. Spec Care Dentist. 2019; 39: 158– 165. https://doi.org/10.1111/scd.12357, which has been published in final form at https://doi.org/10.1111/scd.12357. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.