University of Oulu

Tiisanoja, A, Syrjälä, A‐M, Tertsonen, M, et al. Oral diseases and inflammatory burden and Alzheimer's disease among subjects aged 75 years or older. Spec Care Dentist. 2019; 39: 158– 165. https://doi.org/10.1111/scd.12357

Oral diseases and inflammatory burden and Alzheimer’s disease among subjects aged 75 years or older

Saved in:
Author: Tiisanoja, Antti1; Syrjälä, Anna-Maija1,2,3; Tertsonen, Miia1;
Organizations: 1Unit of Oral Health Sciences Research, University of Oulu, Oulu, Finland
2Dental Training Clinic, Social and Health Services, Oulu, Finland
3Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
4Institute of Dentistry, University of Eastern Finland, Kuopio, Finland
5Faculty of Medicine, University of Oulu, Oulu, Finland
6School of Pharmacy, University of Eastern Finland, Kuopio, Finland
7Research Center of Geriatric Care, University of Eastern Finland, Kuopio, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019102334322
Language: English
Published: John Wiley & Sons, 2019
Publish Date: 2020-01-29
Description:

Abstract

Aim: To study whether dental caries, periodontal disease, and stomatitis, and the related inflammatory burden associate with diagnosed Alzheimer’s disease (AD) and dementia among older people.

Methods: The study population included 170 individuals aged ≥75 years. The primary outcome was diagnosed AD and the secondary outcome was any types of diagnosed dementia. Information about participants’ oral diseases and the related inflammatory burden was based on the clinical oral examination. Relative risks (RRs) and confidence intervals (CIs) were estimated using regression models.

Results: Dental caries, the presence of ≥3 carious teeth (RR: 3.47, 95% CI: 1.09–11.1) and the number of carious teeth (RR: 1.24, CI: 1.11–1.39), and inflammatory burden (RR: 1.44, CI: 1.04–2.01) were associated with a higher likelihood of having AD. Also, periodontal disease and stomatitis were associated, although nonstatistically, with AD and dementia. The risk estimates for any type of dementia were in most cases lower than for AD.

Conclusion: Oral diseases and the related inflammatory burden were in most cases associated more strongly with diagnosed AD than dementia in general. Of the oral diseases studied, the strongest association was between dental caries and AD.

see all

Series: Special care in dentistry
ISSN: 0275-1879
ISSN-E: 1754-4505
ISSN-L: 0275-1879
Volume: 39
Issue: 2
Pages: 158 - 165
DOI: 10.1111/scd.12357
OADOI: https://oadoi.org/10.1111/scd.12357
Type of Publication: A1 Journal article – refereed
Field of Science: 313 Dentistry
Subjects:
Funding: The original GeMS study was supported by the Social Insurance Institute and the City of Kuopio.
Copyright information: © 2019 Special Care Dentistry Association and Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Tiisanoja, A, Syrjälä, A‐M, Tertsonen, M, et al. Oral diseases and inflammatory burden and Alzheimer's disease among subjects aged 75 years or older. Spec Care Dentist. 2019; 39: 158– 165. https://doi.org/10.1111/scd.12357, which has been published in final form at https://doi.org/10.1111/scd.12357. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.