Tiisanoja, A, Syrjälä, A‐M, Komulainen, K, et al. Anticholinergic burden and dry mouth among Finnish, community‐dwelling older adults. Gerodontology. 2018; 35: 3– 10. https://doi.org/10.1111/ger.12304
Anticholinergic burden and dry mouth among Finnish, community-dwelling older adults
|Author:||Tiisanoja, Antti1,2; Syrjälä, Anna-Maija1,2,3; Komulainen, Kaija4,5;|
1Unit of Oral Health Sciences Research, University of Oulu, Oulu, Finland
2Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland
3Dental training clinic, Social and Health services, City of Oulu, Finland
4Social and Health Centre of Kuopio, Kuopio, Finland
5Institute of Dentistry, University of Eastern Finland, Kuopio, Finland
6Kuopio Research Center of Geriatric Care, University of Eastern Finland, Kuopio, Finland
7Department of Social Pharmacy, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
8Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Kuopio, Finland
|Online Access:||PDF Full Text (PDF, 0.3 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019102334326
John Wiley & Sons,
|Publish Date:|| 2019-10-23
Objective: The aim was to study whether the anticholinergic burden of drugs is related to xerostomia and salivary secretion among community‐dwelling elderly people.
Background: Anticholinergic drugs have been shown to be a risk factor for dry mouth, but little is known about the effects of cumulative exposure to anticholinergic drugs measured by anticholinergic burden on salivary secretion or xerostomia.
Methods: The study population consisted of 152 community‐dwelling, dentate, non‐smoking, older people from the Oral Health GeMS study. The data were collected by interviews and clinical examinations. Anticholinergic burden was determined using the Anticholinergic Drug Scale (ADS). A Poisson regression model with robust error variance was used to estimate relative risks (RR) with 95% confidence intervals (CI 95%).
Results: Participants with a high‐anticholinergic burden (ADS ≥ 3) were more likely to have xerostomia (RR: 3.17; CI: 1.44–6.96), low‐unstimulated salivary flow (<0.1 mL/min; RR: 2.31, CI: 1.22–4.43) and low‐stimulated salivary flow (<1.0 mL/min; RR: 1.50, CI: 0.80–2.81) compared to reference group (ADS 0). In participants with a moderate anticholinergic burden (ADS 1–2), all the risk estimates for xerostomia, unstimulated and stimulated salivary secretion varied between 0.55 and 3.13. Additional adjustment for the total number of drugs, antihypertensives and sedative load caused only slight attenuation of the risk estimates.
Conclusion: A high‐anticholinergic burden was associated with low‐unstimulated salivary secretion and xerostomia.
|Pages:||3 - 10|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
The GeMS study has been supported by the Social Insurance Institute and the City of Kuopio. A personal grant was given to Antti Tiisanoja by Finnish Dental Society Apollonia. We thank Paula Pesonen for her statistical guidance.
© 2017 John Wiley & Sons A/S and The Gerodontology Association. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Tiisanoja, A, Syrjälä, A‐M, Komulainen, K, et al. Anticholinergic burden and dry mouth among Finnish, community‐dwelling older adults. Gerodontology. 2018; 35: 3– 10. https://doi.org/10.1111/ger.12304 , which has been published in final form at https://doi.org/10.1111/ger.12304 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.