University of Oulu

Karppinen SM, Heljasvaara R, Gullberg D et al. Toward understanding scarless skin wound healing and pathological scarring [version 1; peer review: 2 approved]. F1000Research 2019, 8(F1000 Faculty Rev):787 (https://doi.org/10.12688/f1000research.18293.1)

Toward understanding scarless skin wound healing and pathological scarring [version 1; peer review: 2 approved]

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Author: Karppinen, Sanna-Maria1,2; Heljasvaara, Ritva1,2,3,4; Gullberg, Donald3,4;
Organizations: 1Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
2Biocenter Oulu, University of Oulu, Oulu, Finland
3Department of Biomedicine, University of Bergen, Bergen, Norway
4Centre for Cancer Biomarkers (CCBIO), University of Bergen, Bergen, Norway
5Oulu Center for Cell-Matrix Research, PEDEGO Research Unit, University of Oulu, Oulu, Finland
6Medical Research Center and Department of Dermatology, University of Oulu/Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019102434619
Language: English
Published: F1000Research, 2019
Publish Date: 2019-10-24
Description:

Abstract

The efficient healing of skin wounds is crucial for securing the vital barrier function of the skin, but pathological wound healing and scar formation are major medical problems causing both physiological and psychological challenges for patients. A number of tightly coordinated regenerative responses, including haemostasis, the migration of various cell types into the wound, inflammation, angiogenesis, and the formation of the extracellular matrix, are involved in the healing process. In this article, we summarise the central mechanisms and processes in excessive scarring and acute wound healing, which can lead to the formation of keloids or hypertrophic scars, the two types of fibrotic scars caused by burns or other traumas resulting in significant functional or aesthetic disadvantages. In addition, we discuss recent developments related to the functions of activated fibroblasts, the extracellular matrix and mechanical forces in the wound environment as well as the mechanisms of scarless wound healing. Understanding the different mechanisms of wound healing is pivotal for developing new therapies to prevent the fibrotic scarring of large skin wounds.

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Series: F1000Research
ISSN: 2046-1402
ISSN-E: 2046-1402
ISSN-L: 2046-1402
Volume: 8
Article number: 787
DOI: 10.12688/f1000research.18293.1
OADOI: https://oadoi.org/10.12688/f1000research.18293.1
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
3111 Biomedicine
Subjects:
Funding: The research of S-MK, RH and TP is supported by the Academy of Finland (grant 284605), the Jane and Aatos Erkko Foundation, and the Sigrid Jusélius Foundation. DG and RH are supported by the Research Council of Norway (Centre of Excellence [CCBIO] grant ID, 223250), and KT is supported by the Academy of Finland (grant 295738) and the Sigrid Jusélius Foundation.
Academy of Finland Grant Number: 284605
Detailed Information: 284605 (Academy of Finland Funding decision)
Copyright information: © 2019 Karppinen SM et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  https://creativecommons.org/licenses/by/4.0/