University of Oulu

Mäkelä KA, Leppäluoto J, Jokelainen J, Jämsä T, Keinänen-Kiukaanniemi S and Herzig K-H (2019) Effect of Physical Activity on Plasma PCSK9 in Subjects With High Risk for Type 2 Diabetes. Front. Physiol. 10:456. doi: 10.3389/fphys.2019.00456

Effect of physical activity on plasma PCSK9 in subjects with high risk for type 2 diabetes

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Author: Mäkelä, Kari Antero1; Leppäluoto, Juhani1; Jokelainen, Jari2,3;
Organizations: 1Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, Oulu, Finland
2Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
3Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland
4Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
6Health Center of Oulu, Oulu, Finland
7Healthcare and Social Services of Selänne, Pyhäjärvi, Finland
8Biocenter Oulu, University of Oulu, Oulu, Finland
9Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznań, Poland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.4 MB)
Persistent link:
Language: English
Published: Frontiers Media, 2019
Publish Date: 2019-10-28


Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a liver serine protease regulating LDL cholesterol metabolism. PCSK9 binds to LDL receptors and guides them to lysosomes for degradation, thus increasing the amount of circulating LDL cholesterol. The aim of the study was to investigate associations between physical activity and plasma PCSK9 in subjects with high risk for type 2 diabetes (T2D).

Methods: Sixty-eight subjects from both genders with a high risk for T2D were included to a randomized controlled trial with a 3-month physical activity intervention. Physical activity intensities and frequencies were monitored throughout the intervention using a hip worn portable accelerometer. The plasma was collected before and after intervention for analysis of PCSK9 and cardiovascular biomarkers.

Results: Plasma PCSK9 did not relate to physical activity although number of steps were 46% higher in the intervention group than in the control group (p < 0.029). Total cholesterol was positively correlated with plasma PCSK9 (R = 0.320, p = 0.008), while maximal oxygen uptake was negatively associated (R = −0.252, p = 0.044). After the physical activity intervention PCSK9 levels were even stronger inversely associated with maximal oxygen uptake (R = −0.410, p = 0.0008) and positively correlated with HDL cholesterol (R = 0.264, p = 0.030). Interestingly, plasma PCSK9 levels were higher in the beginning than at the end of the study.

Conclusion: The low physical activity that our subjects with high risk for T2D could perform did not influence plasma PCSK9 levels. Intervention with higher physical activities might be more effective in influencing PCSK9 levels.

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Series: Frontiers in physiology
ISSN: 1664-042X
ISSN-E: 1664-042X
ISSN-L: 1664-042X
Volume: 10
Article number: 456
DOI: 10.3389/fphys.2019.00456
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Funding: The study was funded in part by University of Oulu Hospital Fund.
Copyright information: © 2019 Mäkelä, Leppäluoto, Jokelainen, Jämsä, Keinänen-Kiukaanniemi and Herzig. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.