Myofibroblasts in oral potentially malignant disorders : is it related to malignant transformation?
|Author:||Coletta, R. D.1; Salo, T.1,2,3|
1Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazi
2Unit of Cancer Research and Translational Medicine, Faculty of Medicine and Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland
3Department of Pathology, Institute of Oral and Maxillofacial Disease, Helsinki University Hospital, University of Helsinki and HUSLAB, Helsinki, Finland
|Online Access:||PDF Full Text (PDF, 0.1 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019102835084
John Wiley & Sons,
|Publish Date:|| 2019-02-26
In oral cancer, acquisition of α‐smooth muscle actin (α‐SMA)‐positive fibroblasts, known as myofibroblasts or carcinoma‐associated fibroblasts (CAF), is an important event for progression and metastasis. However, the contribution of myofibroblasts in oral potentially malignant disorders (OPMD) remains controversial. This systematic review provides evidence that immunodetection of myofibroblasts may identify oral submucous fibrosis (OSMF) with high risk of malignant transformation, but does not represent an auxiliary tool to predict the malignant potential of leukoplakia and erythroplakia, the most common OPMD.
|Pages:||84 - 88|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved. This is the peer reviewed version of the following article: Coletta, RD, Salo, T. Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?. Oral Dis. 2018; 24: 84– 88. https://doi.org/10.1111/odi.12694, which has been published in final form at https://doi.org/10.1111/odi.12694. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.