University of Oulu

Oksanen, P, Tulppo, MP, Auvinen, J, et al. Associations of fitness and physical activity with orthostatic responses of heart rate and blood pressure at midlife. Scand J Med Sci Sports. 2019; 29: 874– 885. https://doi.org/10.1111/sms.13398

Associations of fitness and physical activity with orthostatic responses of heart rate and blood pressure at midlife

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Author: Oksanen, Päivi1; Tulppo, Mikko P.2,3; Auvinen, Juha4,5;
Organizations: 1Institute of Biomedicine, Sports and Exercise Medicine, University of Eastern Finland, Kuopio, Finland
2Research Unit of Internal Medicine, University of Oulu, Oulu, Finland
3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
4Center for Life Course Health Research, University of Oulu, Oulu, Finland
5Unit of Primary Care, Oulu University Hospital, Oulu, Finland
6Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
7Diagnostic Imaging, Oulu University Hospital, Oulu, Finland
8NordLab Oulu and Department of Clinical Chemistry, University of Oulu, Oulu, Finland
9Department of Sports and Exercise Medicine, Oulu Deaconess Institute Foundation, Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019110136226
Language: English
Published: John Wiley & Sons, 2019
Publish Date: 2020-01-29
Description:

Abstract

Cardiorespiratory fitness (CRF) and physical activity (PA) are associated with autonomic function, but their associations to orthostatic autonomic responses are unclear in epidemiological setting. We hypothesized that higher CRF and PA would associate with higher immediate vagal responses and lower incidence of adverse findings during orthostatic test. At age of 46, 787 men and 938 women without cardiorespiratory diseases and diabetes underwent an orthostatic test (3‐minutes sitting, 3‐minutes standing) with recording of RR intervals (RRi) and blood pressure (BP) by finger plethysmography. Acute responses of RRi (30:15 ratio) and BP were calculated. CRF was measured by a submaximal step test and daily amount of moderate‐to‐vigorous PA (MVPA) for 2 weeks by wrist‐worn accelerometer. Lifelong PA was based on questionnaires at ages of 14, 31, and 46. High CRF was significantly associated with higher RRi 30:15 ratio (adjusted standardized β = 0.17, P < 0.001) and milder acute decrease of systolic BP while standing (β = 0.10, P = 0.001), while MVPA was not (β = 0.04 for RRi 30:15 ratio and β = 0.05 for systolic BP acute response). High lifelong PA was significantly associated with higher RRi 30:15 ratio (β = 0.08, P = 0.002) but not with acute systolic BP response. Those in the lowest tertile of CRF had 9.2‐fold risk (P = 0.002) of having postural orthostatic tachycardia syndrome compared to more fit. Cardiorespiratory fitness and lifelong physical activity, but not current physical activity, were independently associated with higher cardiac vagal response to orthostasis. The present results underscore the importance fitness and lifelong physical activity in prevention of abnormal autonomic function and related cardiovascular risk.

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Series: Scandinavian journal of medicine & science in sports
ISSN: 0905-7188
ISSN-E: 1600-0838
ISSN-L: 0905-7188
Volume: 29
Issue: 6
Pages: 874 - 885
DOI: 10.1111/sms.13398
OADOI: https://oadoi.org/10.1111/sms.13398
Type of Publication: A1 Journal article – refereed
Field of Science: 312 Clinical medicine
315 Sport and fitness sciences
Subjects:
Funding: This work was supported by University of Oulu [grant number 24000692], Oulu University Hospital [grant number 24301140], European Regional Development Fund [grant number 539/2010 A31592], the Academy of Finland [grant number 267435], Ministry of Education and Culture [grant numbers 86/686/2014, 43/626/2015, 17/626/2016], the Paulo Foundation, Infotech Oulu, Finland, and the Finnish Foundation for Cardiovascular Research. We thank the late professor Paula Rantakallio (launch of NFBC1966), the participants in the 46y study, and the NFBC project center.
Academy of Finland Grant Number: 267435
Detailed Information: 267435 (Academy of Finland Funding decision)
Copyright information: © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Oksanen, P, Tulppo, MP, Auvinen, J, et al. Associations of fitness and physical activity with orthostatic responses of heart rate and blood pressure at midlife. Scand J Med Sci Sports. 2019; 29: 874– 885. https://doi.org/10.1111/sms.13398, which has been published in final form at https://doi.org/10.1111/sms.13398. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.