University of Oulu

Konstari S, Sares-Jäske L, Heliövaara M, Rissanen H, Knekt P, Arokoski J, et al. (2019) Dietary magnesium intake, serum high sensitivity C-reactive protein and the risk of incident knee osteoarthritis leading to hospitalization—A cohort study of 4,953 Finns. PLoS ONE 14(3): e0214064. https://doi.org/10.1371/journal.pone.0214064

Dietary magnesium intake, serum high sensitivity C-reactive protein and the risk of incident knee osteoarthritis leading to hospitalization : a cohort study of 4,953 Finns

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Author: Konstari, Sanna1; Sares-Jäske, Laura2; Heliövaara, Markku2;
Organizations: 1 Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Finland
2Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland
3 Department of Physical and Rehabilitation Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
4 Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland
5 Finnish Institute of Occupational Health, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019110436475
Language: English
Published: Public Library of Science, 2019
Publish Date: 2019-11-04
Description:

Abstract

Objectives: To study whether low dietary magnesium (Mg) intake and serum high sensitivity C-reactive protein (hs-CRP) predict the development of clinical knee osteoarthritis (OA).

Methods: The cohort consisted of 4,953 participants of a national health examination survey who were free of knee and hip OA at baseline. Information on the incidence of knee OA leading to hospitalization was drawn from the National Care Register for Health Care. During the follow-up of 10 years, 123 participants developed incident knee OA. Dietary magnesium intake was assessed on the basis of a food frequency questionnaire from the preceding year. We used Cox’s proportional hazards model to estimate the strength of the association between the tertiles of dietary Mg intake and incident knee OA, adjusted for baseline age, gender, energy intake, BMI, history of physical workload, leisure time physical activity, injuries, knee complaints, the use of Mg supplements, and serum hs-CRP levels.

Results: At baseline, dietary Mg intake was inversely associated with serum hs-CRP even after adjustment for all the potential confounding factors. During the follow-up, the adjusted hazard ratios (with their 95% confidence intervals) for incident knee OA in dietary Mg intake tertiles were 1.00, 1.28 (0.78–2.10), and 1.38 (0.73–2.62); the p value for trend was 0.31. Serum hs-CRP level at baseline did not predict incident knee OA.

Conclusions: The results do not support the hypothesis that low dietary Mg intake contributes to the development of clinical knee OA, although Mg intake is inversely associated with serum hs-CRP level.

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Series: PLoS one
ISSN: 1932-6203
ISSN-E: 1932-6203
ISSN-L: 1932-6203
Volume: 14
Issue: 3
Article number: e0214064
DOI: 10.1371/journal.pone.0214064
OADOI: https://oadoi.org/10.1371/journal.pone.0214064
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Subjects:
Copyright information: © 2019 Konstari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
  https://creativecommons.org/licenses/by/4.0/