University of Oulu

Kauppila, J., Johar, A., Lagergren, P., Postoperative complications and health-related quality of life 10 years after esophageal cancer surgery, Annals of Surgery, 2019, Ahead of Print, ISSN: 0003-4932, DOI: 10.1097/SLA.0000000000002972

Postoperative complications and health-related quality of life 10 years after esophageal cancer surgery

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Author: Kauppila, Joonas H.1,2,3; Johar, Asif1; Lagergren, Pernilla1
Organizations: 1Surgical Care Sciences, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, 17176 Stockholm, Sweden
2Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland
3Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, 17176 Stockholm, Sweden
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019110536736
Language: English
Published: Wolters Kluwer, 2019
Publish Date: 2020-10-31
Description:

Abstract

Objective: To evaluate the impact of postoperative complications on health-related quality of life (HRQOL) up to 10 years after surgery for esophageal cancer.

Background: The impact of postoperative complications on HRQOL past 5 years is unknown.

Methods: Some 616 patients undergoing open esophageal cancer surgery between April 2, 2001 and December 31, 2005 in Sweden were enrolled in this population-based, nationwide, and prospective cohort study. Exposure was the occurrence of predefined postoperative complications, and the outcome was HRQOL evaluated by validated European Organization for Research and Treatment of Cancer questionnaires at 6 months, 3, 5, and 10 years after surgery. Linear mixed models, adjusted for longitudinal HRQOL in the general population and confounders, provided mean score differences (MDs) with 95% confidence intervals (CIs) for each HRQOL item and scale in patients with or without postoperative complications.

Results: At 10 years, 104 (17%) patients were alive and 92 (88%) answered the HRQOL questionnaires. Of these, 37 (40%) had at least 1 predefined postoperative complication. Twelve of the 25 scales and items were significantly worse in patients with postoperative complications 10 years after surgery, for example, physical function (MD −15, 95% CI −24 to −7), fatigue (MD 16, 95% CI 5–26), pain (MD 18, 95% CI 7–30), dyspnea (MD 15, 95% CI 2–27), insomnia (MD 20, 95% CI 8–32), and eating problems (MD 14, 95% CI 3–24) compared to patients without complications.

Conclusions: Postoperative complications are associated with considerably impaired HRQOL up to 10 years after esophageal cancer surgery.

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Series: Annals of surgery
ISSN: 0003-4932
ISSN-E: 1528-1140
ISSN-L: 0003-4932
Volume: Ahead of print
Issue: Ahead of print
Pages: 1 - 24
DOI: 10.1097/SLA.0000000000002972
OADOI: https://oadoi.org/10.1097/SLA.0000000000002972
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
Copyright information: © 2019 Wolters Kluwer Health, Inc. All rights reserved. This is an accepted manuscript of an article published in the journal Annals of Surgery. The Definitive Version of Record can be found online at: https://doi.org/10.1097/SLA.0000000000002972.