University of Oulu

Kauppila, J.H., Helminen, O., Kytö, V. et al. Ann Surg Oncol (2018) 25: 326.

Short-term outcomes following minimally invasive and open esophagectomy : a population-based study from Finland and Sweden

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Author: Kauppila, Joonas H.1,2; Helminen, Olli2,3; Kytö, Ville4,5;
Organizations: 1Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
2Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospita, lOulu, Finland
3Department of Surgery, Central Finland Central Hospital, Jyväskylä, Finland
4Heart Center, Turku University Hospital, Turku, Finland
5Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
6Division of Cancer Studies, King’s College London and Guy’s and St Thomas’ NHS Foundation Trust, London, UK
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
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Language: English
Published: Springer Nature, 2018
Publish Date: 2019-11-06


Background: Population-based studies comparing minimally invasive esophagectomy (MIE) and open esophagectomy (OE) relative to 90-day postoperative mortality are needed.

Objective: The aim of this study was to compare short-term outcomes following these two techniques for esophageal cancer.

Methods: Patients undergoing MIE (n = 217) or OE (n = 1397) for esophageal cancer between 2007 and 2014 were identified from nationwide complete registries in Finland and Sweden. The primary outcome was 90-day mortality, and secondary outcomes were 30-day mortality, length of hospital stay, and 30- and 90-day readmission rate. Results were adjusted for age, sex, comorbidity, tumor histology, surgery year, and country.

Results: Ninety-day mortality rates were 4.1% (n = 9 of 217) for MIE and 6.8% (n = 95 of 1397) for OE; 90-day mortality was halved after MIE [adjusted hazard ratio (HR) 0.49, 95% confidence interval (CI) 0.24–0.99]. There was no difference in 30-day mortality (adjusted HR 0.87, 95% CI 0.29–2.66). Median hospital stay was 15 days for MIE and 16 days for OE (adjusted β −0.17, standard error 0.08, p = 0.030). The 30-day readmission rates were 8.9% after MIE and 12.0% after OE (adjusted HR 0.57, 95% CI 0.34–0.94), while the 90-day readmission rates were 28.8% and 33.6%, respectively, without a statistically significant difference (adjusted HR 0.82, 95% CI 0.61–1.10).

Conclusions: This population-based study from Finland and Sweden revealed lower 90-day mortality, shorter hospital stay, and lower 30-day readmission rates after MIE compared with OE for esophageal cancer. These findings support the use of minimally invasive approaches.

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Series: Annals of surgical oncology
ISSN: 1068-9265
ISSN-E: 1534-4681
ISSN-L: 1068-9265
Volume: 25
Issue: 1
Pages: 326 - 332
DOI: 10.1245/s10434-017-6212-9
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Funding: This study was supported by grants from Sigrid Juselius Foundation (JHK), Orion Research Foundation (JHK), Swedish Research Council (JL), and the Swedish Cancer Society (JL).
Copyright information: © Society of Surgical Oncology 2017. This is a post-peer-review, pre-copyedit version of an article published in Annals of Surgical Oncology. The final authenticated version is available online at: