University of Oulu

Miika Arvonen, Lauri J. Virta, Tytti Pokka, Liisa Kröger, Paula Vähäsalo, Cow's Milk Allergy in Infancy and Later Development of Juvenile Idiopathic Arthritis: A Register-Based Case-Control Study, American Journal of Epidemiology, Volume 186, Issue 2, 15 July 2017, Pages 237–244, https://doi.org/10.1093/aje/kwx060

Cow’s milk allergy in infancy and later development of juvenile idiopathic arthritis : a register-based case-control study

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Author: Arvonen, Miika1,2,3; Virta, Lauri J.4; Pokka, Tytti1,2,5;
Organizations: 1Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
2PEDEGO Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
3Department of Pediatrics, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
4Research Department, Social Insurance Institution, Turku, Finland
5Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019110636906
Language: English
Published: Oxford University Press, 2017
Publish Date: 2019-11-06
Description:

Abstract

We examined the association between cow’s milk allergy (CMA) and juvenile idiopathic arthritis (JIA). The material for this case-control study was collected from national registers of all children born in Finland between 2000 and 2010 and diagnosed with JIA (n = 1,298) and age-, sex-, and place-matched controls (n = 5,179). We identified 235 children with CMA; 66 of these children also had JIA. A conditional logistic regression analysis was performed to evaluate the association between CMA and JIA and to test whether exposure to antibiotics would be a covariate for this association. In boys (but not in girls), a diagnosis of CMA and the use of hypoallergenic formula in infancy were associated with the later development of JIA (odds ratio = 2.4, 95% confidence interval: 1.6, 3.6). The association was most evident in boys who were diagnosed with JIA before age 3 years or diagnosed with CMA with predominantly gastrointestinal symptoms. There was no statistically significant additive interaction between CMA and antibiotic exposure in the later development of JIA. These associations may reflect impaired maturation of intestinal immunity and integrity in boys with a risk of JIA. Predisposing factors related to JIA pathogenesis seem to display a sex-linked disparity.

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Series: American journal of epidemiology
ISSN: 0002-9262
ISSN-E: 0002-9262
ISSN-L: 0002-9262
Volume: 186
Issue: 2
Pages: 237 - 244
DOI: 10.1093/aje/kwx060
OADOI: https://oadoi.org/10.1093/aje/kwx060
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
3123 Gynaecology and paediatrics
Subjects:
Funding: This work was supported by grants from the Finnish Pediatric Research Foundation, the Finnish Rheumatology Research Foundation, the Scandinavian Rheumatology Research Foundation, the Kuopio University Hospital Research Foundation, the Finnish Medical Foundation, the Finnish Cultural Foundation, the Alma and K. A. Snellman Foundation (Oulu, Finland), and the Päivikki and Sakari Sohlberg Foundation.
Copyright information: © The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This is a pre-copyedited, author-produced version of an article accepted for publication in American Journal of Epidemiology following peer review. The version of record Miika Arvonen, Lauri J. Virta, Tytti Pokka, Liisa Kröger, Paula Vähäsalo, Cow's Milk Allergy in Infancy and Later Development of Juvenile Idiopathic Arthritis: A Register-Based Case-Control Study, American Journal of Epidemiology, Volume 186, Issue 2, 15 July 2017, Pages 237–244, https://doi.org/10.1093/aje/kwx060 is available online at: https://doi.org/10.1093/aje/kwx060.