University of Oulu

Susanna Savukoski, Hannele Mäkelä, Juha Auvinen, Jari Jokelainen, Katri Puukka, Tapani Ebeling, Eila Suvanto, Maarit Niinimäki, Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study, The Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 7, July 2019, Pages 2701–2711, https://doi.org/10.1210/jc.2018-02025

Climacteric status at the age of 46 : impact on metabolic outcomes in population-based study

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Author: Savukoski, Susanna1,2; Mäkelä, Hannele1,2; Auvinen, Juha2,3,4;
Organizations: 1Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, 90029 Oulu, Finland
2Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, 90014 Oulu, Finland
3Centre for Life Course Health Research, University of Oulu, 90014 Oulu, Finland
4Oulunkaari Health Centre, 91100 Ii, Finland
5Unit of General Practice, Oulu University Hospital, 90029 Oulu, Finland
6Centre for Life Course Epidemiology and Systems Medicine, University of Oulu, 90014 Oulu, Finland
7NordLab Oulu, Oulu University Hospital, 90029 Oulu, Finland
8Department of Clinical Chemistry, University of Oulu, 90014 Oulu, Finland
9Department of Internal Medicine, Oulu University Hospital and University of Oulu, 90029 Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 4.7 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019110636929
Language: English
Published: Endocrine society, 2019
Publish Date: 2020-02-08
Description:

Abstract

Context: Menopausal transition is associated with increased cardiovascular risks. Available data on the effect of earlier climacterium on these risks are limited.

Objective: To compare cardiovascular risk-associated parameters at the ages of 14, 31, and 46 in relation to climacteric status at the age of 46.

Design, Setting, and Participants: A prospective cohort study including 2685 women from the Northern Finland Birth Cohort 1966.

Main Outcome Measures: Follicle-stimulating hormone, body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), blood pressure (BP), body composition, cholesterol levels, testosterone (T) levels, free androgen index (FAI), high-sensitivity C-reactive protein (hs-CRP), and liver enzymes.

Results: Women who were climacteric at the age of 46 had lower BMIs (P = 0.029), T levels (P = 0.018), and FAIs (P = 0.009) at the age of 31. At the age of 46, they had less skeletal muscle (P < 0.001), a higher fat percentage (P = 0.016), higher cholesterol levels [total cholesterol (P < 0.001), low-density lipoprotein cholesterol (P < 0.001), high-density lipoprotein cholesterol (HDL-C; P = 0.022), and triglycerides (P = 0.008)], and higher alanine aminotransferase (P = 0.023) and γ-glutamyltransferase (P < 0.001) levels compared with preclimacteric women. Waist circumference, WHR, BP, and hs-CRP levels did not differ between the groups. Of the climacteric women, 111/381 were using hormone-replacement therapy (HRT). In subanalysis that excluded the HRT users, triglycerides, HDL-C, and body fat percentage did not differ among the groups.

Conclusions: Earlier climacterium is associated with mainly unfavorable metabolic changes.

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Series: Journal of clinical endocrinology & metabolism
ISSN: 0021-972X
ISSN-E: 1945-7197
ISSN-L: 0021-972X
Volume: 104
Issue: 7
Pages: 2701 - 2711
DOI: 10.1210/jc.2018-02025
OADOI: https://oadoi.org/10.1210/jc.2018-02025
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Subjects:
Funding: This work was supported by the University Hospital of Oulu (Finland), University of Oulu Scholarship Foundation (Finland), and the Finnish Menopause Society.
Copyright information: © 2019 Endocrine Society. This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Clinical Endocrinology and Metabolism following peer review. The version of record Susanna Savukoski, Hannele Mäkelä, Juha Auvinen, Jari Jokelainen, Katri Puukka, Tapani Ebeling, Eila Suvanto, Maarit Niinimäki, Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study, The Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 7, July 2019, Pages 2701–2711, https://doi.org/10.1210/jc.2018-02025 is available online at: https://doi.org/10.1210/jc.2018-02025.