Kemi, N A, Eskuri, M, Pohjanen, V‐M, Karttunen, T J & Kauppila, J H ( 2019) Histological assessment of stromal maturity as a prognostic factor in surgically treated gastric adenocarcinoma. Histopathology 75, 882– 889. https://doi.org/10.1111/his.13934
Histological assessment of stromal maturity as a prognostic factor in surgically treated gastric adenocarcinoma
|Author:||Kemi, Niko A.1; Eskuri, Maarit2; Pohjanen, Vesa-Matti2;|
1Cancer and Translational Medicine Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
2Cancer and Translational Medicine Research Unit, Medical Research Center, University of Oulu
3Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
|Online Access:||PDF Full Text (PDF, 0.9 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019110737086
John Wiley & Sons,
|Publish Date:|| 2020-06-07
Aims: Histological assessment of stromal maturity is a potential prognostic factor in colorectal cancer, but its applicability in gastric adenocarcinoma is completely unknown. The aim of this study was to evaluate the feasibility and prognostic significance of assessing stromal maturity in gastric adenocarcinoma.
Methods and results: This study was conducted retrospectively in a cohort of 583 gastric adenocarcinoma patients treated surgically in Oulu University Hospital, Finland between 1983 and 2016. The original diagnostic slides were used for assessment of stromal maturity. Patients were divided into mature stroma and immature stroma groups, and stromal maturity was analysed in relation to 5‐year and overall survival (OS). The primary outcome of the study was 5‐year survival, and the secondary outcome was OS. The kappa‐coefficient for interobserver agreement was 0.609. Patients with immature stroma had worse 5‐year survival compared to patients with mature stroma [adjusted hazard ratio (HR) = 1.32, 95% confidence interval (CI) = 1.06–1.64]. Stromal maturity was significantly associated with 5‐year survival in intestinal‐type subgroup (adjusted HR = 0.63, 95% CI = 1.20–2.21), but not in the diffuse‐type subgroup (adjusted HR = 1.21, 95% CI = 0.87–1.70).
Conclusions: Stromal maturity is an independent prognostic factor in gastric adenocarcinoma, and it can be analysed with moderate reproducibility.
|Pages:||882 - 889|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This study was supported by grants from Vatsatautien Tutkimussäätiö (N.K.), the Sigrid Jusélius Foundation (J.H.K.), the Finnish Cancer Foundation (J.H.K.), the Orion Research Foundation (J.H.K.), the Thelma Mäkikyrö Foundation (J.H.K.) and the Mary and Georg C. Ehrnroot Foundation (J.H.K.).
© 2019 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Kemi, N A, Eskuri, M, Pohjanen, V‐M, Karttunen, T J & Kauppila, J H ( 2019) Histological assessment of stromal maturity as a prognostic factor in surgically treated gastric adenocarcinoma. Histopathology 75, 882– 889, which has been published in final form at https://doi.org/10.1111/his.13934. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.